Pure mediastinal seminoma about a case report.

Mediastinal Seminoma is one of the malignant germ cell tumors of the mediastinum. It is a rare tumor that represents only 1%-4% of mediastinal tumors. We report the case of a patient treated at the Oncology Center of Oujda for a pure primitive seminoma of the mediastinum, with a review of the literature to assess the epidemiological, clinical, therapeutic, and prognostic characteristics of this pathology. This is a 25-year-old man whose aunt is being treated for breast cancer and who complained of persistent dry cough with asthenia without any other associated signs. The initial imaging revealed a voluminous locally advanced tumor process in the anterior and middle mediastinum. Tumor markers Alpha-fetoprotein (AFP) and beta-subunit of chorionic gonadotrophic hormone (BHCG) were normal, as well as testicular ultrasound. The CT- guided transthoracic biopsy with anatomopathological study and immunohistochemistry was in favor of a pure seminoma. The treatment consisted of primary chemotherapy with BEP protocol. The response was favorable with a significant reduction in tumor size estimated at 90%. The residual tumor was inoperable due to its intimate contact with the vascular structures and was treated with external radiotherapy at a total dose of 36 Gy. The evolution at 20 months after treatment was in favor of a good clinical and radiological evolution.

[A rare case of botryoid sarcoma of the uterine cervix: case report]. / Sarcome botryoïde du col utérin, une localisation exceptionnelle: à propos d'un cas.

Botryoid sarcoma is a subtype of rhabdomyosarcoma affecting soft tissues and exceptionally the cervix. We here report the case of an 18-year-old female patient presenting to the emergency department with a feeling of pelvic heaviness, metrorrhagia and urinary retention. Gynecological examination showed budding mass of the uterine cervix. The biopsy showed botryoid sarcoma. Radiological evaluation revealed heterodense cervico-isthmic corporeal mass measuring 97 / 87 mm, without adenopathies or effusions or tumors at other sites. Treatment involved neoadjuvant chemotherapy with vincristine - adriamycin and cyclophosphamide (V-A-C), followed by surgery (total hysterectomy without adnexal preservation). After a follow-up of 3 years, the patient is still in clinical and radiological remission.