[Influence of betamethasone on the vascular resistance in human placenta perfused in vitro]. / Wplyw betametazonu na opór naczyniowy lozyska ludzkiego perfundowanego in vitro.

The study was carried out on 48 human placentas perfused in vitro. Betamethasone was administered into the arterial system in the following single doses: 0.4 mg, 2 mg, 10 mg. It was found that betamethasone decreases the pressure of perfusion in different ways depending on the dose. A statistically significant decrease in perfusion pressure was observed in 30th minute of the experiment after administering 2 mg while a dose of 10 mg induced a significant perfusion pressure in 30th and 60th minute of the experiment. The relaxation of the blood vessels of the placenta under the influence of betamethasone was attributed to the action of dopamine on the dopaminergic receptors of the vessels and glucocorticoids modifying this action. The results of the experiments point to a positive action of betamethasone on the blood vessels of human placenta.

[Consumption of glucose under the influence of propranolol in human placentas perfused in vitro]. / Zuzycie glukozy pod wplywem propranololu w lozyskach ludzkich perfundowanych in vitro.

The consumption of glucose under the influence of various doses of propranolol in human placentas perfused in vitro was evaluated every 30 minutes during a two-hour perfusion. In the experiment the authors did not find a significant influence of propranolol on the level of the glucose consumption. The authors found a fourfold differentiation of glucose consumption between particular placentas. In the experiment these values differed from 2.63 mumol/g/h to 10.27 mumol/g/h.