ABSTRACT
40 rabbits were used in the experiments, where 10 animals were in control group, and 3 groups of the animals were treated with naphthalene oil obtained from various pit-holes NN 39, 54 and 88. The treatment course included 10 applications of naphthalene oil, which was placed on lateral body surface, 10 x 10 cm, a dose of 1.0 ml/kg, within 10 min. A state of lipid peroxidation was evaluated by measurement of hydroperoxides, diene conjugates and malonic dialdehyde in rabbit blood. Some decrease in content of lipoperoxides was observed in rabbits after the course of naphthalene oil treatment and the oil from the pit-hole 54 exhibited the highest effect. These results may be involved in evaluation of the naphthalene oil medicinal effects as well as in working out recommendations to use the naphthalene oil not from usual reservoir, but namely from pit-hole 54 for treatment of patients with impaired lipid metabolism.
Subject(s)
Lipid Peroxidation/drug effects , Naphthalenes/pharmacology , Oils/pharmacology , Animals , Lipid Peroxides/blood , Malondialdehyde/blood , RabbitsABSTRACT
Native naphthalene oil was used for skin applications in 100 rabbits, resin-free naphthalene oil was used for skin applications in 30 rabbits and 50 animals were administered with resin-free naphthalene per os. Quantitative and qualitative alterations of individual fatty acids were estimated in rabbit blood plasma before and after these naphthalene treatments. Distinct decrease in content of lauric, myristic, pentadecanoic, palmitic, margarinic and stearic acids as well as increase of oleic, linoleic and arachidonic acids were observed after the treatment course consisting of 10 naphthalene procedures. The ratio of unsaturated/saturated fatty acids was increased after all the naphthalene treatments. The data obtained suggest that naphthalene therapy may be used in health resort treatment of some disorders related to impairment of lipid metabolism.
