ABSTRACT
Sixty patients with acute odontogenic infections were randomly allocated to oral treatment with azithromycin 500 mg/day once-daily for three days (n = 30) or spiramycin 3,000,000 units three-times daily for seven days (n = 30). Baseline and post-treatment oral specimens were collected from patients to test for pathogenic bacteria. Aerobic bacteria were tested using the Kirby-Bauer disc diffusion method, and anaerobic bacteria with a broth microdilution method, for their susceptibility to azithromycin and spiramycin. A greater incidence of resistance was found in the spiramycin group than in the azithromycin group. The bacteriological assessment showed that the normal balance of microflora was re-established in 67% of patients treated with azithromycin vs 53% in the group treated with spiramycin. Clinical cure was higher in the azithromycin treatment group (97%) compared with the spiramycin group (73%). These results indicate that three-day azithromycin, possibly because of its unusual pharmacokinetics, is more effective than seven-day spiramycin in the treatment of odontogenic infections.
Subject(s)
Bacterial Infections/drug therapy , Erythromycin/analogs & derivatives , Spiramycin/therapeutic use , Tooth Diseases/drug therapy , Azithromycin , Erythromycin/adverse effects , Erythromycin/therapeutic use , Female , Humans , Male , Mouth Diseases/drug therapy , Mouth Diseases/microbiology , Spiramycin/adverse effects , Tooth Diseases/microbiologyABSTRACT
The Authors, after a short review of the literature, report their clinical experience using alpha-cyanoacrylate, a new tissue adhesive. This substance shows haemostatic and adhesive properties and it is useful to protect surgical wounds. On these bases, the alpha-cyanoacrylate shows definite directions in oral and maxillo-facial surgery.
