ABSTRACT
The results of pathomorphological research of internal organs of rats in hypoxical hypoxia and in the action of the antioxidant dihydroguersitine in acute hypoxia. Lt shows that DHQ causes favourable morphological changes in internal organs in acute hypoxia.
Subject(s)
Antioxidants/pharmacology , Brain/drug effects , Heart/drug effects , Liver/drug effects , Quercetin/analogs & derivatives , Anaerobiosis/drug effects , Animals , Brain/pathology , Flavonols/pharmacology , Liver/pathology , Male , Myocardium/pathology , Quercetin/pharmacology , Rats , Rats, Inbred StrainsABSTRACT
The experiments with rats treated with gentamicin showed that nitrogen excretion function of the kidneys did not significantly change in the animals 3 months after induction of pyelonephritis, while in the animals not treated with the antibiotic there was a significant increase in excretion of alkaline phosphatase with urine. The nitrogen excretion function of the kidneys was not affected by gentamicin, except an increase in the urea blood level. Gentamicin promoted a significant rise in excretion of enzymes with urine, especially that of alkaline phosphatase. Treatment of healthy animals with gentamicin resulted in the increased excretion of alkaline phosphatase with urine and increased urea blood levels which was evident of the nephrotoxic effect of the aminoglycoside antibiotic. When such animals were treated with furosemide, the renal excretion of the enzyme and the blood creatinine urea levels decreased. Therefore, furosemide lowered nephropathy induced by gentamicin. The increase in the activity of the urine enzymes may be due to inflammatory changes in the kidney parenchymal on the one hand and the pephrotoxic effect of the drugs on the other hand. The urine enzymes may be used as important diagnostic tests in cases with kidney affections and indicators of safe treatment with nephrotoxic antibiotics.
