ABSTRACT
The spinal mechanism of the phantom pain origin is proved. The underlying factors are: segmentary spinal denervation hypersensitivity and attenuation of the descending inhibitory influence. The pathogenetic treatment of phantom pains is proposed by means of an associated treatment by GABA-ergic drug--Baclofen and alpha-2--adrenomimetic--Clofelin. Good effects of the proposed scheme of treatment confirm the correctness of the presented ideas of pathogenesis of phantom pains.
Subject(s)
Amputation Stumps/innervation , Arm/innervation , Hyperesthesia/complications , Leg/innervation , Phantom Limb/etiology , Adult , Aged , Baclofen/administration & dosage , Clonidine/administration & dosage , Drug Therapy, Combination , Female , Humans , Hyperesthesia/drug therapy , Male , Middle Aged , Phantom Limb/drug therapySubject(s)
Arm Injuries/surgery , Fractures, Bone/surgery , Leg Injuries/surgery , Adolescent , Adult , Aged , Female , Femoral Fractures/surgery , Fibula/injuries , Humans , Humeral Fractures/surgery , Male , Methods , Middle Aged , Radius Fractures/surgery , Tibial Fractures/surgery , Ulna Fractures/surgerySubject(s)
Fractures, Bone/surgery , Adolescent , Adult , Aged , Female , Humans , Male , Methods , Middle AgedABSTRACT
Clinical examination of patients with diseases of the lungs and locomotor system during the surgical treatment and experiments in animals has shown that sodium hydroxybutyrate used as an anesthetizing drug under conditions of the neuroleptic analgesia fails to provide an effective defense against the surgical trauma. This is shown by the instability in the hemodynamic indices, metabolic shifts and the presence of nociceptive viscero-somatic reflexes.