Subject(s)
Bridged Bicyclo Compounds, Heterocyclic/chemistry , Ethanolamines/chemistry , Germanium/chemistry , Organosilicon Compounds/chemistry , Antifungal Agents/pharmacology , Bacteria/drug effects , Bacteria/metabolism , Chemistry/methods , Disinfectants/pharmacology , Fungi/drug effects , Microbiology , Silicates/chemistry , Water/chemistryABSTRACT
The content of aldosterone (A) was studied in rat adrenal glands, blood plasma and peripheral tissues--in the myocardium, skeletal muscles, thymus and liver--1 h after the administration of alpha-adrenergic stimulator noradrenaline and beta-adrenergic stimulator isoprenaline and after simultaneous administration of alpha- and beta-blockers and a sympatholytic agent (pyrroxan, propranolol and bretylium tosylate respectively). Adrenergic stimulation did not change the level of A in the adrenal glands, raised its blood concentration and, to a greater extent, its level in the peripheral tissues. A marked increase in the blood concentration of A resulted from isoprenaline and its accumulation in tissues--from noradrenaline. A decrease in the level of adrenergic activity considerably lowered the A content in the adrenal glands, blood plasma and peripheral tissues excluding the myocardium where this value was higher than in the blood.