ABSTRACT
Activation of procoagulant hemostasis and signs of increased consumption of thrombocytes were indications for the treatment of patients with hemorrhagic erysipelas by means of heparine (60 patients) and trental (30 patients). Heparine was introduced subcutaneously as "minidoses" by means of electrophoresis into the inflammation focus. Heparine produced a positive effect on hemostasis and fibrinolysis, favoured rapid disappearance of the hemorrhagic syndrome, prevention of complications of erysipelas. Trental effected positively thrombocytic hemostasis, local manifestations of the hemorrhagic syndrome but did not prevent the development of thrombophlebitis as complication of the disease.
Subject(s)
Erysipelas/drug therapy , Hemorrhage/drug therapy , Heparin/therapeutic use , Pentoxifylline/therapeutic use , Adolescent , Adult , Aged , Blood Coagulation/drug effects , Drug Evaluation , Erysipelas/blood , Erysipelas/complications , Female , Hemorrhage/blood , Hemorrhage/etiology , Humans , Male , Middle AgedABSTRACT
The localization of bound IgG, IgA, IgM and component C3 of the complement in the focus of skin lesion in patients with different forms of erysipelas has been studied by the method of direct immunofluorescence. The presence of fixed immune complexes and component C3 in the affected areas of the skin at the acute period of the disease and their absence in the healthy areas of the skin have been established, which seems to be indicative of the presence of the local immunocomplex process in erysipelas. This process is one of the mechanisms of erysipelatous inflammation.