ABSTRACT
The results of an histochemical and microscopic study of the APUD cells carried on gastric biopsies are reported. Endocrine cell hyperplasia, microscopically detected, was particularly evident in atrophic gastritis (type A chronic gastritis) and adenomas. The presence of the APUD cells confirmed by electronmicroscopy, which revealed granules of 200 NM with a central nucleus and a membrane-separating electron-lucent ring, gives a further contribution to the hypothesis of a possible association between endocrine cell hyperplasia and intestinal metaplasia.
Subject(s)
APUD Cells , Gastric Mucosa/cytology , Adenoma/pathology , Adult , Aged , Biopsy , Chronic Disease , Dyspepsia/pathology , Gastritis, Atrophic/pathology , Histocytochemistry , Humans , Microscopy, Electron , Middle Aged , Polyps/pathology , Stomach Neoplasms/pathology , Stomach Ulcer/pathologyABSTRACT
The Authors, after pointing out how incidence of gastric cancer has been reducing last decades, dwell upon environmental and genetic factors that may be linked to the occurrence of such neoplasia. After reporting the data of a retrospective study, they consider the survival rates related to the clinical stage and site of the tumor as well as the therapeutic treatment adopted. They conclude that, even though today gastric cancer is a neoplasia with a still unfavourable prognosis, an early diagnosis and a proper therapeutic procedure may give sufficient guarantees of success.
Subject(s)
Adenocarcinoma/mortality , Carcinoma/mortality , Stomach Neoplasms/mortality , Adenocarcinoma/pathology , Adenocarcinoma/surgery , Adult , Aged , Aged, 80 and over , Carcinoma/pathology , Carcinoma/surgery , Female , Humans , Male , Middle Aged , Neoplasm Staging , Prognosis , Retrospective Studies , Stomach Neoplasms/pathology , Stomach Neoplasms/surgerySubject(s)
Adenoma/pathology , Stomach Neoplasms/pathology , Adult , Aged , Female , Humans , Immunoenzyme Techniques , Male , Middle Aged , Mucins/analysis , Muramidase/analysisABSTRACT
The authors, in the light of the data supplied by the literature, and through a careful analysis of their recent casuistry, based upon the observation of 48 cases of duodenal diverticula, propose a modern reviewing of the topic. After illustrating the etiopathogenetic, anatomo-pathological and clinical features of such disease, the Authors dwell upon the diagnostic and therapeutical problems involved, and point out the importance of a correct diagnostic iter and a consequent exact surgical indication. As a conclusion, they affirm the surgical treatment of duodenal diverticula, not exempt from risks, should be only reserved to cases rebellious to the medical treatment or severely complicate.
