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Adv Exp Med Biol ; 892: 253-269, 2016.
Article in English | MEDLINE | ID: mdl-26721277

ABSTRACT

Inorganic ions such as phosphate and sulfate are essential macronutrients required for a broad spectrum of cellular functions and their regulation. In a constantly fluctuating environment microorganisms have for their survival developed specific nutrient sensing and transport systems ensuring that the cellular nutrient needs are met. This chapter focuses on the S. cerevisiae plasma membrane localized transporters, of which some are strongly induced under conditions of nutrient scarcity and facilitate the active uptake of inorganic phosphate and sulfate. Recent advances in studying the properties of the high-affinity phosphate and sulfate transporters by means of site-directed mutagenesis have provided further insight into the molecular mechanisms contributing to substrate selectivity and transporter functionality of this important class of membrane transporters.


Subject(s)
Anion Transport Proteins/metabolism , Gene Expression Regulation, Fungal , Proton-Phosphate Symporters/metabolism , Saccharomyces cerevisiae Proteins/metabolism , Saccharomyces cerevisiae/metabolism , Sodium-Phosphate Cotransporter Proteins, Type III/metabolism , Anion Transport Proteins/chemistry , Anion Transport Proteins/genetics , Cell Membrane/chemistry , Cell Membrane/metabolism , Ion Transport , Mutagenesis, Site-Directed , Phosphates/metabolism , Proton-Phosphate Symporters/chemistry , Proton-Phosphate Symporters/genetics , Saccharomyces cerevisiae/genetics , Saccharomyces cerevisiae Proteins/chemistry , Saccharomyces cerevisiae Proteins/genetics , Signal Transduction , Sodium-Phosphate Cotransporter Proteins, Type III/chemistry , Sodium-Phosphate Cotransporter Proteins, Type III/genetics , Structure-Activity Relationship , Substrate Specificity , Sulfate Transporters , Sulfates/metabolism
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