ABSTRACT
Background: Soils have been studied and classified in terms of their physical and chemical characteristics, while the knowledge about biodiversity and the ecosystem processes that they support is lagging behind. Furthermore, the advance in scientific knowledge contributed by different researchers is dispersed and it is necessary to collect it to bring the big picture into focus. Today, it is possible to have the findings and data collected by different researchers, compile them and, based on technological advances, have tools that allow the information to be analysed in its entirety. The main objective of this work is to compile and systematise all the bibliographic information available on the main organisms that make up biodiversity in the soil: Acari, Collembola and Crassiclitellata in Argentina. This information will then allow us to link the composition and structure of the soil community with processes and flows in the ecosystem, and to estimate them at different scales and in soils with different anthropic impact. The database presented here gathers presence information on the mentioned taxa, their geographical location for the entire country, while preserving the identity and authorship of each scientific work retrieved. The taxonomic range of the organisms of the edaphic biota collected in this database ranges from class to subspecies and are registered, based on the taxonomic level reported by the original author in their research. The publications were obtained from Google Scholar, Scopus and JSTOR. In addition, records were added from INEDES theses, library searches, information requested from authors cited in other articles and unpublished works. In total, information was collected from 224 scientific publications, as well as personal information requested directly from some authors. The total number of registered individuals so far is 4838 of which 3049 specimens correspond to Acari, 944 to Classiclitellata and 845 belong to Collembola. New information: This work is the first to gather, in a single publication, the entire dataset for all the Acari, Collembola and Clitellata recorded for Argentina.
ABSTRACT
El cáncer colorrectal (CCR) es la cuarta causa de mortalidad por cáncer en Colombia y en el mundo, en ambos sexos; por esta razón, es considerado un problema de salud pública. El CCR es altamente heterogéneo en su fenotipo y genotipo, lo que está en relación con las diferentes vías de carcinogénesis descritas que implican diferentes mecanismos de progresión y agresividad de la enfermedad. Las vías clásicas, supresora y mutadora, se caracterizan por una serie de alteraciones genéticas relacionadas con los cambios fenotípicos de la progresión morfológica en la secuencia adenoma-carcinoma. Las vías alternas, originadas por mutaciones en los genes, BRAF y KRAS, se relacionan con la progresión de pólipo aserrado a carcinoma. Conocer estas vías es muy importante para comprender la enfermedad de manera integral y profundizar en el estudio de sus mecanismos de control, que incluyen: diagnóstico temprano, tratamiento y seguimiento.
Colorectal cancer (CRC) is ranked fourth among causes of cancer mortality in Colombia and in the world, for both genders; it is therefore regarded as a public health issue. CRC´s phenotype and genotype are highly heterogeneous, a fact related to the various carcinogenic pathways described, and which is also implicated in the different progression mechanisms and the aggressiveness of the disease. The classic pathways, suppressive and mutable, are characterized by a series of genetic alterations related to phenotype changes in the morphologic progression of the adenoma-carcinoma sequence. The alternate pathways, originated by BRAF and KRAS gene mutations, are linked to the serrated polyp progression to carcinoma. Knowledge of these pathwaysis very important in achieving a fuller understanding of the disease and for broadening the study of mechanisms for its control; these include: early diagnosis, treatment and follow-up.
