Oral leukoplakia: nuclear volume and mitotic index.

Biopsies from patients with oral leukoplakia were studied in order to detect caryometrical changes and determine patterns of mitotic index. Mean nuclear volume was always larger in parakeratotic lesions than orthokeratotic ones in all layers (p less than 0.05). A correlation between the basal cell layer and lower spinous stratum, and between upper spinous stratum and lower one was also observed in both types of keratinization, but the rate of increase was higher in orthokeratotic lesions while the mitotic index was higher in parakeratotic lesions (p less than 0.01). It seems that the damage concerned originally the basal cell layers.

Posibles mecanismos de la degeneracion celular en macrofagos infectados con BCG in vitro y en los granulomas leprosos. / Possible mechanisms of cell degeneration in macrophages infested with B.C.G. in vitro in leprous granulomas

Se realiza un estudio al microscopio optico y electronico de la interaccion de micobacterias BCG in vitro y M. leprae in situ con el proposito de abundar en los posibles mecanismos de muerte de los macrofagos. Se encontro en la interacion con el BCG dos posibles mecanismos: la autofagocitosis y la clasmatosis y en el M. leprae, una acumulacion lipidica dependiente de los mononucleares fagociticos que pueden ayudar a explicar como ocurre la muerte de los macrofagos

The effect of cyproheptadine chlorhydrate on rat embryonic development.

The teratogenic effect of cyproheptadine chlorhydrate was studied in Wistar rats. Rats were given the substance by gastric intubation on days 6-15 of pregnancy in two experimental series. In the first series rats were treated at doses of 25 and 50 mg/kg/d and in the second one they received 15, 25 and 35 mg/kg/d. Controls received only an equivalent volume of water by the same route. Doses of 25 or more mg/kg/d are highly embryotoxic. At 15 mg/kg/d the effects were relatively minor. The major anomalies caused by the drug were edema and abnormal ossification of the ribs. Some other malformations were also found: craniorrhachischisis, cleft lip, cleft palate, hypoplastic limbs, micrognathy, micromelia, and vascular damage.

[Subpolar lepromatous leprosy. A histological and ultrastructural study of a case]. / Lepra lepromatosa subpolar: Estudio hístico y ultraestructural de un caso.

Leproma material from a female patient with a previous diagnosis of lepromatous leprosy underwent clinical, histopathological and electrone microscope studies. Following a year under rifampicin treatment it was found that the histic lesions corresponded to those described by Ridley (1974) within the clinical picture of regressive subpolar lepromatous leprosy. Electrone microscope studies of the cells composing the lesions were conducted; their ultrastructural appearance does not markedly differ from that reported for the polar form, but regarding the lack of acid phosphatase reaction for the giant multinucleated and vacuolated cells.