1.
Org Lett
; 13(14): 3690-3, 2011 Jul 15.
Article
in English
| MEDLINE
| ID: mdl-21699171
ABSTRACT
The first total synthesis of isofregenedadiol, a bicyclic diterpene isolated from H. Viscosum, is reported starting from a D-(-)-pantolactone chiral pool. A one-pot quadruple reaction sequence comprising an enyne ring-closing metathesis/cross-metathesis/Diels-Alder/aromatization for the construction of a target skeleton is the highlight of the present synthesis.