Tumores de ovario ``border line´´ / No disponible

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Testosterone and 17 beta-oestradiol secretion of the human ovary. I. normal young women, and premenopausal women with endometrial hyperplasia.

Testosterone and 17 beta-oestradiol were determined in blood obtained from the ovarian veins of 26 women, 16 of whom were young and regularly ovulating and menstruating, and 10 of whom were premenopausal with uterine bleedings and endometrial hyperplasia. The concentrations of these two hormones in the cubital veins of the premenopausal women were also determined. It was found that the concentrations of the two hormones were not significantly greater in the premenopausal women than in the control group of young normally ovulating and menstruating women in the periovulatory phase of the menstural cycle, but that the ovarian secretion rates of both hormones, particularly of testosterone, were considerably greater in the premenopausal women. In these women the concentrations of both hormones were significantly lower in the cubital veins than in the ovarian veins. The conclusion is that the augmented oestrogenic effect on the endometrium and on other target organs of premenopausal women with endometrial hyperplasia may be due not only to an increased ovarian secretion rate of estradiol, but also and more specifically to an increased ovarian secretion rate of testosterone, and to the rapid vonversion of this hormone into oestradiol in the periphery.

Testosterone and 17 beta-oestradiol secretion of the human ovary. II. normal postmenopausal women, postmenopausal women with endometrial hyperplasia and postmenopausal women with adenocarcinoma of the endometrium.

A study of the concentration of testosterone and of 17 beta-estradiol in blood drawn from the ovarian and cutal veins of normal oestrogen-deficient postmenopausal women and of postmenopausal women with signs of oestrogen activity, and the subsequent computation of the ovarian production rates of these two hormones, show that in the latter group of women there is a high ovarian secretion of testosterone. The theory is advanced that this ovarian-secreted testosterone is rapidly converted into 17 beta-oestradiol, and that, by thus increasing the levels of circulating oestrogens, ovarian-secreted testosterone contributes, albeit indirectly, to endometrial hyperplasia and possibly to endometrial carcinoma.

Anterior pituitary of the macaca mulatta monkey: an electron microscopic view.

An electron microscopic study was performed of the cells which constitute thar anterior pituitary of the Macaca Mulatta female monkey. The characteristics of each cell are described, and the findings are illustrated schematically. Different forms of hormonal secretion are observed and described.