Subject(s)
Facial Dermatoses/surgery , Laser Therapy/methods , Lichen Planus/surgery , Pigmentation Disorders/surgery , Biopsy , Facial Dermatoses/pathology , Female , Humans , Lichen Planus/pathology , Middle Aged , Pigmentation Disorders/pathology , Radiation-Protective Agents/therapeutic use , Treatment OutcomeSubject(s)
Leukemia, Large Granular Lymphocytic/complications , Pruritus/etiology , Skin Neoplasms/complications , Aged , Biopsy/methods , Female , Humans , Leukemia, Large Granular Lymphocytic/pathology , Pruritus/pathology , Sjogren's Syndrome/complications , Skin Neoplasms/pathology , Treatment OutcomeSubject(s)
Connective Tissue Diseases/pathology , Hamartoma/pathology , Subcutaneous Tissue , Back , Humans , Infant , MaleABSTRACT
No disponible
Subject(s)
Male , Infant , Humans , Connective Tissue Diseases/pathology , Hamartoma/pathology , Subcutaneous Tissue , BackSubject(s)
Sneddon Syndrome/diagnosis , Adult , Erythema/complications , Humans , Hypertension/complications , Male , Recurrence , Stroke/complicationsABSTRACT
No disponible
Subject(s)
Male , Adult , Humans , Sneddon Syndrome/diagnosis , Stroke/complications , Erythema/complications , Hypertension/complications , RecurrenceSubject(s)
Apocrine Glands , Hidrocystoma/diagnosis , Sweat Gland Neoplasms/diagnosis , Female , Fingers , Humans , Middle AgedABSTRACT
Extraskeletal osteosarcoma represents approximately 1% of soft tissue sarcomas and approximately 4% of all osteosarcomas. It is therefore much rarer than osteosarcoma arising primarily in bone. Skin as a primary site has seldom been reported. This report describes an extraskeletal osteosarcoma of the skin under a previously electrodessicated actinic keratosis.
Subject(s)
Desiccation/methods , Keratosis/therapy , Osteosarcoma/pathology , Skin Neoplasms/pathology , Aged , Aged, 80 and over , Facial Neoplasms/pathology , Facial Neoplasms/surgery , Female , Humans , Keratosis/pathology , Osteosarcoma/surgery , Prognosis , Skin Neoplasms/surgeryABSTRACT
Necrobiosis lipoidica (NL) is a disease of collagen. Squamous cell carcinomas developing in areas of chronic ulceration and scarring have been well documented in a variety of skin diseases but rarely in areas of necrobiosis lipoidica. The case history of a 76-year-old female is presented, whose squamous cell carcinoma appeared 30 years after the diagnosis of necrobiosis lipoidica. The clinical and histopathological picture is described, stressing the importance of the unusual association of the two pathologies in the prognostic.
Subject(s)
Carcinoma, Squamous Cell/complications , Necrobiosis Lipoidica/complications , Skin Neoplasms/complications , Aged , Carcinoma, Squamous Cell/pathology , Female , Humans , Skin Neoplasms/pathologySubject(s)
Amyloidosis/pathology , Skin Diseases/pathology , Aged , Amyloidosis/diagnosis , Humans , Male , Skin Diseases/diagnosisABSTRACT
No disponible
Subject(s)
Child, Preschool , Male , Humans , Thiabendazole , Antinematodal Agents , Diagnosis, Differential , Larva Migrans , EosinophiliaABSTRACT
OBJECTIVE: To map the locus for susceptibility to psoriasis in patients with psoriatic arthritis. METHODS: Seventy-four patients with psoriatic arthritis and 95 patients with psoriasis vulgaris were included in this study. Polymorphic genes and microsatellite markers centromeric (C1_2_5) and telomeric (C1_4_4, OTF3, HCR and the corneodesmosin gene) to HLA-C were studied in an association analysis. Typing was also performed on a control population of 104 matched donors. RESULTS: The allele Cw*0602 was associated both with psoriasis [49 vs 21%, Pc<0.0003; odds ratio (OR)=3.6, aetiological factor (AF)=0.72] and with psoriatic arthritis (62 vs 21%, Pc<0.000001; OR=6.1, AF=0.83). In psoriatic patients a susceptibility region telomeric to HLA-C that includes C1_4_4 (56 vs 22%, Pc<0.0002; OR=4.39, AF=0.77), OTF3 (85 vs 60%, Pc<0.0002; OR=3.7, AF=0.73) and HCR (63 vs 26%, Pc<0.00001; OR=3.8, AF=0.74) was observed. In psoriatic arthritis patients the susceptibility region was delimited by HLA-C and C1_4_4 (384 allele, 56 vs 22%, Pc<0.0002; OR=4.37, AF=0.77). CONCLUSIONS: Comparing the susceptibility regions associated with the two diseases, an overlapping interval of 100 kb between HLA-C and OTF3, which might contain the psoriasis gene, can be defined.
