[Compliance, efficacy and tolerability of the therapeutic regimen recommended by National Consensus on Tuberculosis]. / Cumplimiento, eficacia y tolerancia de la pauta terapéutica preconizada por el Consenso Nacional sobre la Tuberculosis.

BACKGROUND: To study the degree of adhesion, efficacy, and tolerance of therapeutic guidelines advocated by the National Consensus on tuberculosis. METHODS: A prospective study of a cohort of 84 patients receiving a diagnosis of tuberculosis in a Basic General Health Area between 1-3-1993 and 28-2-1994 treated with the regimen recommended by the National Council. The patients were evaluated clinically and microbiologically during the treatment and during twelve months follow-up. RESULTS: Fifty-two patients (61.9%) were male and 32 (38.1%) female, aged 29.9 +/- 19.7 years (r = 1-84 years). Seventy-four (88.1%) were index cases and 10 (11.4%) household contacts. Eight patients (9.5%) were also infected with HIV, 71 (84.5%) presented pulmonary tuberculosis and 13 (15.5%) extrapulmonary forms. Therapeutic compliance was correct in 80 cases (95.2%) and incorrect in 4 (4.8%). It was well-tolerated in 73 patients (91.2%), there was slight toxicity in five (6.3%) and severe in two (2.5%). Seventy-four patients (88.1%) were cured, there was one therapeutic failure (1.2%) and five relapses (6%). Overall mortality was 4.8% and attributable mortality 1.2%. CONCLUSION: Our results seem to confirm a high degree of adhesion, good tolerance and acceptable therapeutic efficacy of the scheme proposed by the National Council.

Fibrinolytic treatment in primary antiphospholipid syndrome.

We document a 30 y old man with Primary Antiphospholipid Syndrome (PAPS) and thrombosis of the common femoral vein and both the external and common iliac veins, extending to the lower vena cava, which failed to respond to high dose heparin. After three days of fibrinolytic treatment with urokinase there was complete venous recanalization.