Smell-taste dysfunctions in extreme weight/eating conditions: analysis of hormonal and psychological interactions.

(1) The objective of this study is to analyze differences in smell-taste capacity between females in extreme weight/eating conditions (EWC) and (2) to explore the interaction between smell/taste capacity, gastric hormones, eating behavior and body mass index (BMI). The sample comprised 239 females in EWC [64 Anorexia nervosa (AN) and 80 age-matched healthy-weight controls, and 59 obese and 36 age-matched healthy-weight controls]. Smell and taste assessments were performed through "Sniffin' Sticks" and "Taste Strips," respectively. The assessment measures included the eating disorders inventory-2, the symptom check list 90-revised, and The Dutch Eating Behavior Questionnaire, as well as peptides from the gastrointestinal tract [Ghrelin, peptide YY, cholecystokinin]. Smell capacity was differentially associated across EWC groups. Smell was clearly impaired in obese participants and increased in AN (hyposmia in Obesity was 54.3 and 6.4 % in AN), but taste capacity did not vary across EWC. Ghrelin levels were significantly decreased in obese subjects and were related to smell impairment. EWC individuals showed a distinct smell profile and circulating ghrelin levels compared to controls. Smell capacity and ghrelin may act as moderators of emotional eating and BMI.

Lifetime obesity in patients with eating disorders: increasing prevalence, clinical and personality correlates.

OBJECTIVES: The aims of our study were to examine the lifetime prevalence of obesity rate in eating disorders (ED) subtypes and to examine whether there have been temporal changes among the last 10 years and to explore clinical differences between ED with and without lifetime obesity. METHODS: Participants were 1383 ED female patients (DSM-IV criteria) consecutively admitted, between 2001 and 2010, to Bellvitge University Hospital. They were assessed by means of the Eating Disorders Inventory-2, the Symptom Checklist-90-Revised, the Bulimic Investigatory Test Edinburgh and the Temperament and Character Inventory-Revised. RESULTS: The prevalence of lifetime obesity in ED cases was 28.8% (ranging from 5% in anorexia nervosa to 87% in binge-eating disorders). Over the last 10 years, there has been a threefold increase in lifetime obesity in ED patients (p < .001). People with an ED and obesity had higher levels of childhood and family obesity (p < .001), a later age of onset and longer ED duration; and had higher levels of eating, general and personality symptomatology. CONCLUSIONS: Over the last 10 years, the prevalence of obesity associated with disorders characterized by the presence of binge episodes, namely bulimic disorders, is increasing, and this is linked with greater clinical severity and a poorer prognosis.

Personality in non-clinical adolescents with eating disorders.

OBJECTIVE: The aim of this study was to examine whether personality-related differences also exist in non-clinical adolescents with any given type of eating disorder (ED) and whether personality characteristics are associated with changes in the course of the diagnosis. METHOD: An initial sample of 1336 boys and girls (mean age: 11.37, SD = 0.62) was assessed in a two-phase long-term study. A total of 258 subjects were selected from the initial sample (T1) and contacted again 2 years later (T2) (n = 200). These subjects comprise the sample group of this study. Of these, 51 were diagnosed with ED (37 with diagnosis type anorexia (DTA) and 14 with diagnosis type bulimia (DTB)). An experimental version of the Junior Temperament and Character Inventory (JTCI) was applied. RESULTS: Subjects with DTA had significantly higher scores on Reward Dependence and Self-Directedness factors than subjects with no diagnosis or DTB, respectively. Subjects with DTB had higher scores on Novelty Seeking, Harm Avoidance and Spirituality factors than subjects with forms of anorexia or without diagnosed ED. Subjects with ED remission had significantly lower scores on Persistence and Self-Directedness scales. ED incident subjects had significantly higher scores on Harm Avoidance. CONCLUSIONS: Subjects without full-blown syndromes have similar temperament characteristics to subjects with full eating disorders. These results support the theory that non-full-blown syndromes differ from full syndromes only in pathological severity.