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Pediatr Infect Dis J ; 33(7): 731-3, 2014 Jul.
Article in English | MEDLINE | ID: mdl-24445830

ABSTRACT

Vancomycin trough serum concentrations were below therapeutic range (8-15 mg/L) in 58% of 124 pediatric oncology patients receiving 60 mg/kg/d divided qid. Patients <6 and between 6 and 12 years had significantly lower trough concentrations than patients >12 years. A vancomycin dosage of 60 mg/kg/d is inadequate for pediatric oncology patients >12 years.


Subject(s)
Anti-Bacterial Agents/administration & dosage , Anti-Bacterial Agents/pharmacokinetics , Vancomycin/administration & dosage , Vancomycin/pharmacokinetics , Adolescent , Anti-Bacterial Agents/pharmacology , Bacterial Infections/drug therapy , Child , Child, Preschool , Female , Humans , Infant , Male , Neoplasms/complications , Retrospective Studies , Serum/chemistry , Vancomycin/pharmacology
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