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Angew Chem Int Ed Engl
; 58(50): 18177-18181, 2019 12 09.
Article
in English
| MEDLINE
| ID: mdl-31595605
ABSTRACT
A highly convergent strategy for the synthesis of the natural product (-)-rubriflordilactoneâ B, and the proposed structure of (-)-pseudo-rubriflordilactoneâ B, is described. Late stage coupling of diynes containing the respective natural product FG rings with a common AB ring aldehyde precedes rhodium-catalyzed [2+2+2] alkyne cyclotrimerization to form the natural product skeleton, with the syntheses completed in just one further operation. This work resolves the uncertainty surrounding the identity of pseudo-rubriflordilactoneâ B and provides a robust platform for further synthetic and biological investigations.