The impact of the first COVID-19 lockdown in the UK for doctoral and early career researchers.

Doctoral researchers and early career researchers (ECRs) are crucial to producing scientific advancements and represent the future of academic leadership. Their research endeavours were changed radically by lockdowns in response to the COVID-19 pandemic. The aim of this study was to explore the perceived benefits and challenges of the national lockdown in the UK from the perspective of doctoral researchers and ECRs. We present analysis of qualitative survey data from 1,142 doctoral researchers and ECRs on their experiences of the first UK lockdown collected from April 16, 2020-May 14, 2020. Our findings suggest considerable heterogeneity in how the pandemic impacted this key group of academic workers. Challenges arising from the lockdown largely cohered around a poor work environment, limited access to resources, perceptions of pressure, and negative psychological outcomes. Conversely, respondents also highlighted several benefits in the early stages of the pandemic, with the change to working from home creating more time, resulting in greater productivity and a better work-life balance. Collectively, findings indicate the importance of considering the personal circumstances and needs of individual researchers. We discuss the implications for support these researchers require to rebuild their careers in the wake of the initial disruption.

Strangers in a Strange Land: Relations Between Perceptions of Others' Values and Both Civic Engagement and Cultural Estrangement.

Healthy democracies require civic engagement (e.g., voting) from their citizens. Past research has suggested that civic engagement is positively associated with self-transcendence values of care and concern for the welfare of others, and negatively associated with self-enhancement values of self-interest, dominance, and personal success. However, research has yet to address whether people's perceptions of others' values are related to civic engagement. Across three studies with nationally representative samples in the UK and US (Ns ≥ 1,000), we explored how civic engagement relates to (a) perceptions of national values, (b) perceptions of the values of one's typical compatriot, and (c) perceptions of the values encouraged by social and cultural institutions. Study 1 showed that the tendency for British citizens to perceive British culture as valuing self-transcendence was associated with an increased likelihood of voting in the 2015 general election. These findings were replicated for "a typical British person" (Study 2) and "a typical American person" (Study 3); Studies 2 and 3 also found that perceived self-enhancement values of typical compatriots were negatively correlated with reported voting. We also examined how perceptions of others' values relate to cultural estrangement-the feeling of not fitting in one's culture or of being atypical. Like civic engagement, those who perceived less self-transcendence and more self-enhancement in their culture felt more culturally estranged. Mediation analyses in Studies 2 and 3 revealed that estrangement helped to explain the relationship between perceptions of others' values and voting. In sum, the extent to which Brits and Americans perceive that self-transcendence values are strongly held by other citizens is associated with feeling less estranged and with reports of being more civically engaged. In contrast, the perception that these targets hold or promote self-enhancement values is positively associated with feelings of estrangement, to the detriment of civic engagement. Implications for future research and democratic processes are discussed.

Noninvasive Detection of Fetal Aneuploidy Using Next Generation Sequencing.

Cell-free DNA (cfDNA)-based noninvasive prenatal testing (NIPT) utilizing next generation sequencing (NGS) is a highly sensitive and specific approach designed to screen for fetal aneuploidy. NIPT was first introduced in 2011 and has been rapidly adopted in a clinical setting because of the improved performance afforded compared with traditional prenatal serum screening options. We describe a PCR-free, paired-end sequencing-based NIPT, the VeriSeq NIPT Solution. This NIPT screens for fetal aneuploidy of chromosomes 21, 18, 13, X, and Y. Using the validated approach detailed here, users can achieve high sensitivities and specificities for trisomies 21, 18, and 13 as well as sex chromosome aneuploidies with low failure rates. The automated workflow can be completed in 1 day, with only 2 h of hands-on time from a single technician.

The after-school needs and resources of a low-income urban community: surveying youth and parents for community change.

Using a collaborative research approach, this project describes a partnership between community residents and university researchers to develop a comprehensive survey of the after-school needs of a low-income urban community in a large Midwestern city. Surveying parents and children was considered particularly important because the current literature on after-school does not include much input from them, the key stakeholders in programming. By surveying pre- and young adolescent youth (N = 416) and parents (N = 225) in the community, information was gathered to document the need for after-school programming, tap program preferences, and uncover barriers to participation and enrollment. Survey findings revealed significant differences between youth and parent perspectives. Disagreements between youth and parent survey responses suggest that after-school programs in the community should offer a balance of academic, recreational, and social activities, as well as a tutoring or homework component. Further, in order to increase participation and attendance rates, community after-school programs need to address the following barriers to participation: safety, transportation, family responsibilities (e.g., care for siblings, household chores), and access to information about available programs. These findings guided the planning of future after-school programs. The survey results and comparisons between youth and parent data will be presented.

Dieting and the development of eating disorders in obese women: results of a randomized controlled trial.

BACKGROUND: Some investigators fear that dieting may precipitate binge eating and other adverse behavioral consequences. OBJECTIVE: The objective of the study was to examine whether dieting would elicit binge eating and mood disturbance in individuals free of these complications before treatment. DESIGN: A total of 123 obese women were randomly assigned to 1) a 1000 kcal/d diet that included 4 servings/d of a liquid meal replacement (MR); 2) a 1200-1500 kcal/d balanced deficit diet (BDD) of conventional foods; or 3) a nondieting (ND) approach that discouraged energy restriction. All women attended weekly group sessions for 20 wk and biweekly sessions from week 20 to week 40. RESULTS: At week 20, participants in the MR, BDD, and ND groups lost 12.1 +/- 6.7%, 7.8 +/- 6.0%, and 0.1 +/- 2.4% of initial weight, respectively (P < 0.001). During the first 20 wk, there were no significant differences among groups in the number of persons who had objective binge episodes or in reports of hunger or dietary disinhibition. Symptoms of depression decreased significantly more (P < 0.001) in the MR and BDD groups than in ND participants. At week 28, significantly more (P < 0.003) cases of binge eating were observed in MR participants than in the 2 other groups. No differences, however, were observed between groups at weeks 40 or 65 (a follow-up visit). At no time did any participant meet criteria for binge-eating disorder. CONCLUSION: Concerns about possible adverse behavioral consequences of dieting should not dissuade primary care providers from recommending modest energy restriction to obese individuals.

Primary care physicians' attitudes about obesity and its treatment.

OBJECTIVE: This study was designed to assess physicians' attitudes toward obese patients and the causes and treatment of obesity. RESEARCH METHODS AND PROCEDURES: A questionnaire assessed attitudes in 2 geographically representative national random samples of 5000 primary care physicians. In one sample (N = 2500), obesity was defined as a BMI of 30 to 40 kg/m(2), and in the other (N = 2500), obesity was defined as a BMI > 40. RESULTS: Six hundred twenty physicians responded. They rated physical inactivity as significantly more important than any other cause of obesity (p < 0.0009). Two other behavioral factors-overeating and a high-fat diet-received the next highest mean ratings. More than 50% of physicians viewed obese patients as awkward, unattractive, ugly, and noncompliant. The treatment of obesity was rated as significantly less effective (p < 0.001) than therapies for 9 of 10 chronic conditions. Most respondents (75%), however, agreed with the consensus recommendations that a 10% reduction in weight is sufficient to improve obesity-related health complications and viewed a 14% weight loss (i.e., 78 +/- 5 kg from an initial weight of 91 kg) as an acceptable treatment outcome. More than one-half (54%) would spend more time working on weight management issues if their time was reimbursed appropriately. DISCUSSION: Primary care physicians view obesity as largely a behavioral problem and share our broader society's negative stereotypes about the personal attributes of obese persons. Practitioners are realistic about treatment outcomes but view obesity treatment as less effective than treatment of most other chronic conditions.