ABSTRACT
The variation in the third component of human complement (C3) and orosomucoid (ORM1) serum proteins, and 6-phosphogluconate dehydrogenase (6PGD), adenosine deaminase (ADA), esterase D (ESD), and acid phosphatase (ACP1) red cell enzymes was examined in two samples from autochthonous populations living on either side of the Sierra de Gredos range in Central Spain. These results support only a moderate differentiation between Gredos subpopulations, which is discussed in relation to other Iberian Peninsula groups. Allele frequencies in Gredos show a remarkable heterogeneity as contrasted with other Iberian populations for most of the markers examined; relatively high C3*S, ORM1*F, ADA*1, ESD*2, and ACP1*C gene frequencies are characteristics of Gredos samples. This differentiation was more marked for the Northern Gredos population and could be related to the geographical peculiarities of this region.
Subject(s)
Blood Proteins/genetics , Carboxylesterase , Genetic Variation , Polymorphism, Genetic , Acid Phosphatase/blood , Acid Phosphatase/genetics , Adenosine Deaminase/blood , Adenosine Deaminase/genetics , Adult , Alleles , Carboxylic Ester Hydrolases/blood , Carboxylic Ester Hydrolases/genetics , Complement C3/genetics , Erythrocytes/enzymology , Female , Gene Frequency , Geography , Humans , Male , Orosomucoid/genetics , Phosphogluconate Dehydrogenase/blood , Phosphogluconate Dehydrogenase/genetics , SpainABSTRACT
Serum samples of autochthonous individuals from the Garrotxa prepyrenean region, and the Pallars Sobirà valley were screened for HP (Haptoglobin) and ORM (Orosomucoid) types by polyacrylamide isoelectric focusing and electrophoresis. The allele frequencies estimated were HP*1 = 0.3902 and ORM1*S = 0.3697 for Pallars Sobirà, and HP*1 = 0.4161 and ORMS1*S = 0.3691 in the Garrotxa. While our results for the HP system are within the range of variation of the Iberian Peninsula, the ORM1 protein shows a remarkable degree of variation among these populations.
Subject(s)
Haptoglobins/genetics , Orosomucoid/genetics , Polymorphism, Genetic , Humans , Spain/ethnologyABSTRACT
A sample of 121 Piaroa Indians from the Federal Amazonia Territory (Venezuela) was studied for the following serum protein polymorphisms: haptoglobin (HP), group-specific component subtypes (GC), orosomucoid (ORM), third component of complement (C3), transferrin C subtypes (TF) and alpha 1-antitrypsin subtypes (PI). The gene frequencies in the whole sample were: HP1 = 0.821; GC1S = 0.698; GC1F = 0.058; GC2 = 0.244; ORMS = 0.434; C3S = 0.699; C3F = 0.289; C3var = 0.012; TFC1 = 0.955; PIM1 = 0.467; PIM2 = 0.004; PIM3 = 0.529. The studied Piaroa sample came from three different communities: Gavilan, Paria and Alto Carinagua. The distribution of GC, C3 and HP polymorphisms was heterogeneous within the three groups. All the examined serum protein markers were polymorphic, in contrast to some enzymatic markers (ADA, DIA, 6PGD, AK) previously studied, which were shown to be monomorphic in the Piaroa. The results were compared with data from other populations living in the same territory.
