ABSTRACT
OBJECTIVE: To compare the effects of low and conventional doses of tibolone in brachial artery flux parameters among postmenopausal women. METHODS: Between March 2011 and September 2012, 24 postmenopausal women attending Gynecology and Obstetrics Hospital Luis Castelazo Ayala, Mexico City, for hormone replacement therapy were consecutively recruited. The women were alternately assigned to receive a daily dose of either 2.5mg (n=11) or 1.25mg (n=13) of oral tibolone. Before and after treatment, all women underwent a brachial artery Doppler ultrasound. The arterial diameter was measured, and the pulsatility index (PI) and the resistance index (RI) were calculated. A hyperemic stimulus was then induced and these parameters were measured again. RESULTS: Among the 24 women, the time since menopause ranged from 16 to 24 months, and the median treatment duration was 3 months. Both groups showed a significant increase in arterial diameter after treatment. There was no significant difference between the groups in arterial diameter, PI, and RI. The arterial diameter after hyperemic stimulus was significantly lower after treatment than before treatment in both groups. CONCLUSION: Low and conventional doses of tibolone induced similar changes in brachial artery flux parameters among postmenopausal women.
Subject(s)
Brachial Artery/drug effects , Estrogen Receptor Modulators/pharmacology , Norpregnenes/pharmacology , Postmenopause , Administration, Oral , Adult , Brachial Artery/diagnostic imaging , Brachial Artery/metabolism , Dose-Response Relationship, Drug , Estrogen Receptor Modulators/administration & dosage , Female , Hormone Replacement Therapy/methods , Humans , Longitudinal Studies , Mexico , Middle Aged , Norpregnenes/administration & dosage , Time Factors , Ultrasonography, Doppler , Vascular Resistance/drug effectsABSTRACT
OBJECTIVE: To evaluate the differences in visceral fat between women using tibolone and those not using tibolone. METHODS: Sixty-five healthy postmenopausal women were included in the study: 26 who were taking tibolone (2.5 mg/day); and 39 who were not receiving tibolone treatment. Anthropometric measurements were performed, with subcutaneous and visceral fat measured via ultrasound. Differences between the groups were determined via Student t test. RESULTS: There were no significant differences in age (P=0.796), weight (P=0.256), height (P=0.456), body mass index (P=0.08), waist circumference (P=0.420), or waist-hip ratio (P=0.1) between the groups. Hip circumference was significantly lower in the study group than in the control group (97.7 ± 12.2 cm vs 103 ± 8.1cm; P<0.04). There were no significant differences between the groups in subcutaneous fat measurements (P=0.56). There were significantly lower visceral fat measurements (2.8 ± 1.1cm vs 3.9 ± 1.6 cm; P<0.004) and a significantly lower visceral fat-subcutaneous fat ratio (1.1 ± 0.3 vs 1.5 ± 0.7; P<0.005) in the study group than in the control group. CONCLUSION: Postmenopausal women who use tibolone have lower visceral fat measurements than do woman of similar age who do not use tibolone.
