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2.
Article in English | MEDLINE | ID: mdl-8548333

ABSTRACT

The finding that severe measles occurs in immunized as well as nonimmunized human immunodeficiency virus (HIV)-infected individuals suggests that both immunologic memory and the initial response to measles may be impaired by HIV infection. That the initial response is affected was supported by the finding that post-measles immunization titers of HIV-infected babies were significantly lower (p = 0.01) than those of normal babies. Poor immunologic memory was evidenced in HIV-infected children by lower titers than in normal children (p < 0.001) and by a continuing decline in measles antibody that was not arrested by reimmunization. Impaired memory appeared to be associated with defective avidity maturation. HIV-infected babies and infants or children had a significantly lower avidity index (AI) than age-matched normal children (p < 0.01). HIV-infected adults, who were infected with HIV following infection with measles, did not have AI values significantly different from normal adults (p = 0.18) but had significantly greater values than did HIV-infected babies and children (p < 0.01). Thus, in contrast to infants and children who were infected with HIV before measles immunization, the adult immune response to measles was less affected.


Subject(s)
Antibodies, Viral/biosynthesis , HIV Infections/complications , HIV-1 , Measles virus/immunology , Measles/immunology , Adult , Antibody Affinity , CD4 Lymphocyte Count , Child , Child, Preschool , Enzyme-Linked Immunosorbent Assay , Humans , Immunization , Immunization, Secondary , Immunologic Memory , Infant , Measles/prevention & control , Measles Vaccine/administration & dosage , Measles Vaccine/immunology , Measles-Mumps-Rubella Vaccine , Mumps Vaccine/administration & dosage , Mumps Vaccine/immunology , Rubella Vaccine/administration & dosage , Rubella Vaccine/immunology , Vaccines, Combined/administration & dosage , Vaccines, Combined/immunology
3.
Health Phys ; 62(5): 436-8, 1992 May.
Article in English | MEDLINE | ID: mdl-1559813

ABSTRACT

A hybrid detector for measuring fast neutrons in mixed gamma-neutron fields is discussed in this paper. The detector consists of an ionization chamber with components made from a plastic scintillator. Its operation is based on the two detection systems thus combined. Its parameters and domain of applicability are explained. This paper proposes a rapid integral method for measuring the neutron-dose equivalent based on this detector, which allows a good separation of the gamma component.


Subject(s)
Fast Neutrons , Radiometry/instrumentation , Gamma Rays , Radiation Dosage , Scintillation Counting/instrumentation
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