ABSTRACT
Thymomodulin and Thymolymphotropin, biologically active thymus derivative peptides exert recovery effects on the functionality of some membrane bound, mitochondrial and lysosomal enzymes (monoamine oxidase, ATPase, phosphatases, cytochrome oxidase, succinate oxidase) affected by gamma-irradiation. These drugs exert antistress effect by re-establishing the function of hypothalamus-pituitary-adrenal axis and that of lymphoid organs.
Subject(s)
Neurosecretory Systems/radiation effects , Stress, Physiological/physiopathology , Thymus Extracts/pharmacology , Animals , Brain/enzymology , Brain/pathology , Brain/radiation effects , Cell Membrane/enzymology , Gamma Rays , Lymphoid Tissue/enzymology , Lymphoid Tissue/pathology , Lymphoid Tissue/radiation effects , Lysosomes/enzymology , Male , Mitochondria/enzymology , Monoamine Oxidase/metabolism , Neurosecretory Systems/enzymology , Neurosecretory Systems/pathology , Rats , Rats, Wistar , Stress, Physiological/pathologyABSTRACT
Metronidazol, an efficient drug for Trichomonas vaginalis, Lamblia intestinalis and some anaerobic germs, administered in a daily dose of 500 mg/kg body weight for 60 and 40 days in males and females, respectively, produces severe structural alterations (atrophy and cytolysis, more apparent in the testicle) and elicits, a functional impairment as well (modifications in the activity of some enzymes: alkaline and acide-phosphatase, Mg(2+)-ATPase, CyOx, SDH, LDH). These morphological and histoenzymological changes in the steroidogenic formations suggest that Metronidazol severily affects the gametogenesis and hormonogenesis in rat.
Subject(s)
Metronidazole/pharmacology , Ovary/anatomy & histology , Testis/anatomy & histology , Animals , Female , Male , Ovary/drug effects , Ovary/enzymology , Rats , Rats, Inbred Strains , Testis/drug effects , Testis/enzymologySubject(s)
Intestine, Small/drug effects , Liver/drug effects , Procaine/administration & dosage , Animals , Drug Administration Routes , Female , Histocytochemistry , Intestine, Small/enzymology , Intestine, Small/pathology , Liver/enzymology , Liver/pathology , Rats , Rats, Inbred Strains , StomachABSTRACT
Some histological and histoenzymological changes of the small intestine of adult female Wistar rats treated with Madiol were studied. The steroid did not influence the tissular aspect, but obviously stimulatory effects on protein and enzyme reactions were induced. Similar Madiol-action on the small intestine of 21-day-old young rats was observed when the steroid was administered during pregnancy to their mothers, suggesting influences on the embryonic development.
