ABSTRACT
BACKGROUND: The prethrombotic state can be observed in advanced lung cancer patients. The aim of this study is to investigate the relationship between coagulation and fibrinolysis marks on pathophysiological characteristics and prognosis in patients with lung cancer. METHODS: The coagulation and fibgrinolysis marks were detected in sixty patients with lung cancer and twenty normal controls. RESULTS: The D-dimer, fibrinogen degradation products, plasma fibrinogen were significantly higher than those of normal controls. The plasma antithrombin III was significantly lower than those of normal controls. All marks in patients with lung cancer were not related to age, sex, histological classification, the size of the primary tumors, P-TNM stages, distant metastasis. The plasma levels of D-dimer and fibrinogen in patients with lung cancer were negatively correlated to survival. CONCLUSIONS: The patients with lung cancer have abnormal coagulation and fibrinolysis state, these contribute to hypercoagulability state and thrombi. The plasma levels of D-dimer and fibrinogen in patients with lung cancer were correlated with prognosis. The anticoagulability medicine treatment are benefit for the patients with lung cancer.
