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Actas Esp Psiquiatr ; 27(4): 223-7, 1999.
Article in Spanish | MEDLINE | ID: mdl-10469942

ABSTRACT

INTRODUCTION: Several investigations have communicated frequent association between alcohol dependence and depression. METHOD: 21 subjects with DSM-IV criteria for alcohol dependence were included in an open label trial for alcohol withdrawal. At inclusion and along the follow-up none of the probands met DSM-IV criteria for mood disorder. Follow-up included a 15-day detoxification period and 195 days of withdrawal program, including treatment with 20 mg/d of fluoxetine. Occurrence of depressive semiology was measured using the Beck Depression Inventory (BDI) on day 15 (after detoxification), day 75 and day 210 (after withdrawal from ethanol of 195 days). RESULTS: 67% of the sample showed a positive basal BDI (after-detoxification-BDI> 9). Global retention rate after 210 days of follow-up was 57%. All patients who dropped out the investigation before completing the protocol showed a basal BDI in the depressive rank (BDI= 10-63), and maintained depressive scores in this instrument until their abandonment. CONCLUSIONS: Prevalence of <> in this population appears to be high. This clinical feature is frequently ignored because most of the patients do not meet standardized diagnostic criteria for mood disorders. Post-detoxification BDI could be used as a predictive factor of therapeutic result in long-term alcohol withdrawal programs. In addition, in our study fluoxetine showed efficacy in maintaining long-term alcohol abstinence.


Subject(s)
Alcoholism/psychology , Depressive Disorder/diagnosis , Substance Withdrawal Syndrome/diagnosis , Adolescent , Adult , Alcoholism/diagnosis , Catchment Area, Health , Depressive Disorder/drug therapy , Depressive Disorder/epidemiology , Diagnosis, Differential , Female , Fluoxetine/therapeutic use , Follow-Up Studies , Humans , Male , Middle Aged , Prevalence , Psychiatric Status Rating Scales , Selective Serotonin Reuptake Inhibitors/therapeutic use , Severity of Illness Index , Spain , Substance Withdrawal Syndrome/psychology , Syndrome
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