1.
Nihon Shokakibyo Gakkai Zasshi
; 91(5): 1042-6, 1994 May.
Article
in Japanese
| MEDLINE
| ID: mdl-8196199
2.
Neurosci Lett
; 151(1): 51-4, 1993 Mar 05.
Article
in English
| MEDLINE
| ID: mdl-8385761
ABSTRACT
The ammonium ion (NH4+) evoked no response itself but facilitated the GABA-induced Cl- current (ICl) in dissociated rat cortical neurons. The GABA concentration-response curve shifted parallely to the left without changing the maximum response. Reversal potential of GABA response did not change in the presence of NH4+ at the concentration range between 0.1 and 1 mM. Ro 15-1788, a selective benzodiazepine receptor antagonist, did not affect the facilitatory action of NH4+ on GABAA receptor. The results suggest that NH4+ modifies the affinity of GABAA receptor for GABA, without the involvement of benzodiazepine receptors.
