ABSTRACT
PURPOSE: To evaluate the efficacy and safety of intracameral amphotericin B (ICAMB) in the management of fungal keratitis. METHODS: In total, 45 eyes with smear-confirmed fungal keratitis with hypopyon were randomized into three treatment groups: Group I (topical antifungal treatment + oral antifungal); Group II (topical antifungal treatment + ICAMB + oral antifungal); and Group III (topical antifungal treatment + drainage of hypopyon + ICAMB + oral antifungal). The main outcome measures were treatment success rate, time to heal, visual acuity gain, and presence of complications. RESULTS: There were no differences in the treatment success rates (p = 0.66), time to healing (p = 0.18), or mean final visual acuity (logMAR) (p = 0.8) between the three groups. The major complication observed was increased incidence of cataract in group III (40%), though it was statistically insignificant. CONCLUSIONS: ICAMB does not offer any benefit over topical antifungal therapy when performed alone or associated with drainage of hypopyon.
Subject(s)
Amphotericin B/therapeutic use , Antifungal Agents/therapeutic use , Corneal Ulcer/drug therapy , Eye Infections, Fungal/drug therapy , Administration, Oral , Administration, Topical , Adult , Anterior Chamber/drug effects , Corneal Ulcer/microbiology , Eye Infections, Fungal/microbiology , Female , Fungi/isolation & purification , Humans , Male , Middle Aged , Young AdultABSTRACT
Ocular dirofilariasis mostly presents as a subconjunctival or eyelid lesion. Intraocular dirofilarial infestation is rare. We report a case of a young woman who was accidentally detected to have a live motile worm in the anterior segment in one eye and a cystic lesion on the optic disc in the other eye. To our knowledge, bilateral intraocular dirofilariasis has never been reported.
Subject(s)
Anterior Eye Segment/pathology , Aqueous Humor/parasitology , Dirofilariasis/diagnosis , Eye Infections, Parasitic/diagnosis , Adult , Animals , Diagnosis, Differential , Dirofilariasis/parasitology , Eye Infections, Parasitic/parasitology , Female , Humans , Tomography, Optical CoherenceSubject(s)
Choroid/abnormalities , Coloboma/complications , Lens Nucleus, Crystalline/pathology , Lens Subluxation/etiology , Phacoemulsification/adverse effects , Humans , Lens Capsule, Crystalline/injuries , Lens Implantation, Intraocular , Lens Subluxation/surgery , Ligaments , Male , Middle Aged , Prolapse , Visual Acuity , VitrectomyABSTRACT
Choroidal neovascular membranes are a rare cause of decreased vision in children with congenital choroidal and optic nerve colobomas. We report on the regression of coloboma-related choroidal neovascular membranes in 2 children treated with intravitreal bevacizumab. Visual acuity remained improved in both children 2 years after the last injection.
Subject(s)
Angiogenesis Inhibitors/administration & dosage , Antibodies, Monoclonal/administration & dosage , Choroidal Neovascularization , Coloboma/complications , Optic Nerve/abnormalities , Antibodies, Monoclonal, Humanized , Bevacizumab , Child , Child, Preschool , Choroidal Neovascularization/complications , Choroidal Neovascularization/congenital , Choroidal Neovascularization/drug therapy , Female , Humans , Injections, Intraocular , Treatment Outcome , Visual Acuity/drug effectsABSTRACT
Typical ischemic retinal microvascular changes after bone marrow transplantation is a well-established entity and is seen in up to 7% of allogenic transplant recipients. Such cases are characterized by symmetric presence of cotton wool spots, retinal hemorrhages, and multiple microaneurysms and have a good visual prognosis. In this report we describe a case of atypical ischemic maculopathy with poor visual recovery after bone marrow transplantation.
