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The level of orally ingested vitamin C affected the expression of vitamin C transporters and vitamin C accumulation in the livers of ODS rats.
Sone, Yasuko; Ueta, Etsuko; Kodama, Satoru; Sannoumaru, Yasuko; Miyake, Noriko; Sone, Hirohito; Fujiwara, Yoko; Otsuka, Yuzuru; Kondo, Kazuo; Inagaki, Masahiro; Namba, Eiji; Kurata, Tadao; Suzuki, Emiko.
Biosci Biotechnol Biochem ; 75(12): 2394-7, 2011.
Article in English | MEDLINE | ID: mdl-22146724

ABSTRACT

We investigated the effects of vitamin C administration on vitamin C-specific transporters in ODS/ShiJcl-od/od rat livers. The vitamin C-specific transporter levels increased in the livers of the rats not administered vitamin C and decreased in the livers of those administered vitamin C at 100 mg/d, indicating that these transporter levels can be influenced by the amount of vitamin C administered.


Subject(s)
Ascorbic Acid/metabolism , Ascorbic Acid/pharmacology , Gene Expression Regulation/drug effects , Liver/drug effects , Liver/metabolism , Sodium-Coupled Vitamin C Transporters/genetics , Administration, Oral , Animals , Ascorbic Acid/administration & dosage , Hepatocytes/drug effects , Hepatocytes/metabolism , Liver/cytology , Male , RNA, Messenger/genetics , RNA, Messenger/metabolism , Rats
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