1.
Chem Asian J
; 14(23): 4150-4153, 2019 Dec 02.
Article
in English
| MEDLINE
| ID: mdl-31599116
ABSTRACT
The asymmetric synthesis of an aspartic acid derivative, N-succinopyridine, from prochiral starting materials involving dynamic enantioselective crystallization was accomplished without using any external chiral source. The aza-Michael addition reaction of prochiral maleic acid and pyridine afforded racemic conglomerate N-succinopyridine in water. Continuous stirring of the suspension of the reaction mixture with acetic acid promoted gradual deracemization to afford a crystal with an excellent optical purity of 99 % in 71 % yield.