ABSTRACT
A unique case of gallbladder carcinoma with morule-like features and tumor-associated lymphoid proliferation in a 53-year-old man is presented. The surgically resected gallbladder demonstrated a polypoid tumor with a thin stalk, measuring 1.3 x 0.5 cm. Histologically, a well-differentiated tubular adenocarcinoma was accompanied by multiple spindle cell nodules. The stroma of the tumor showed dense lymphocytic infiltrate. Immunohistochemically, the spindled cell nodules were diffusely positive for cytokeratin AE1/AE3 but negative for S-100, NSE, and chromogranin A. The immunohistochemical results considered to be spindle cell nodules were morule-like features. Intranuclear expression of beta-catenin was observed in morule-like features and carcinoma cells. Ki-67 labeling index was 16.7% of carcinoma cells, but Ki-67 immunoreactivity was negative in spindle cell nodules; therefore, morule-like features were considered to represent metaplastic foci of carcinoma cells and not nodular growth of carcinoma cells. Although the exact pathogenesis of marked lymphoid proliferation in the stroma remained unknown, tumor-produced substances may derive from lymphoid proliferation.
Subject(s)
Adenocarcinoma/pathology , Cell Proliferation , Gallbladder Neoplasms/pathology , Lymphoid Tissue/pathology , Adenocarcinoma/diagnosis , Adenocarcinoma/metabolism , Cell Aggregation , Gallbladder Neoplasms/diagnosis , Gallbladder Neoplasms/metabolism , Humans , Male , Middle Aged , beta Catenin/metabolismABSTRACT
We report a case of basaloid carcinoma of the thymus, confirmed by histopathological examination, in a 52-year-old man who underwent complete resection. Local recurrence and lung metastases developed, which were obliterated by radiation therapy. The patient survived for 81 months after surgery. We reviewed the 13 other cases of basaloid carcinoma of the thymus reported in the literature. Presumably, this tumor is radiosensitive and its metastatic route is blood-borne.
