[Oxidative metabolism parameters in newborns with sepsis during the cerebral ischemia of different degrees].

Within the last decade neonatal sepsis remains one of the actual problems of medicine due to its high morbidity and lethality rates. Reference data clarify that in septicaemia pathogenesis a great importance is attributed to the cellular oxidation-reduction imbalance and oxide stress development. A redox imbalance developed during sepsis indicates to the cell's dysfunction. Also central nervous system is one of the first organs, which is damaged during the sepsis. The purpose of our research was the investigation of activity of pro- and antioxidant system in newborn babies with sepsis during the cerebral ischemia of different degrees. It was shown that during the newborns' sepsis the intensity of free-radical oxidation-reduction process was increased remarkably, antioxidant system activity decreased and intensive ESR-signal of HbNO MetHb was fixed in the blood. These changes caused to development of hypoxemia and deep cerebral ischemia.

[Role of oxygen-nitrogen stress in neonatal sepsis].

Reference data indicate on the important role of free radicals of nitrogen and oxygen in the mechanisms of the damage of cells and tissues during neonatal sepsis. Meanwhile these connections play an important role in protecting of the host organism from intervention of microorganisms. The aim of the study was the evaluation of peculiarities of oxidizing metabolism and containing of nitrogen oxide. Low consistence of nitrogen oxide and the disturbance of the intracellular oxidative-resorting balance during neonatal sepsis, especially in premature children, induces insufficiency of immune and antioxidant system, which changes the homeostasis and develops the oxidative stress of the host organism. As it was shown by the results of our study, antibacterial and supportive therapy doesn't provide the important reduction of processes of free radical oxidizing. The last circumstance makes a barrier for improving a clinical condition of the newborns.