ABSTRACT
Juvenile psammomatoid ossifying fibroma is a rare bone-forming tumor seen in craniofacial bones, which affects mainly young patients. We report scintigraphic and SPECT/CT findings of 2 patients diagnosed with this disease. One patient presented with suspicion of fibrous dysplasia and the other with suspected malignancy in the setting of a rapidly growing mass. Both cases highlight the importance of recognizing this type of tumor in young patients with abnormal uptake in paranasal bones and sinuses within the range of potential differential diagnoses including sarcomas, fibrous dysplasia, and odontogenic tumors.
Subject(s)
Bone Neoplasms/diagnostic imaging , Fibroma, Ossifying/diagnostic imaging , Maxillary Neoplasms/diagnostic imaging , Paranasal Sinuses/diagnostic imaging , Single Photon Emission Computed Tomography Computed Tomography , Adolescent , Child , Diagnosis, Differential , Female , Fibrous Dysplasia of Bone/diagnostic imaging , Humans , Maxilla/diagnostic imaging , Nasal Bone/diagnostic imagingABSTRACT
OBJECTIVE: Describe factors associated with aggressive forms of recurrent respiratory papillomatosis (RRP). MATERIALS AND METHODS: One hundred eighty-nine RRP cases diagnosed between 1985 and 2009 were identified in pathological records. HPV was detected by the SPF-10 method with broad spectrum primers, (version 1). RESULTS: 113 patients had only one surgery (less aggressive) and 76, two or more interventions (more aggressive). The likelihood of aggressive lesions decreased with increasing age at diagnosis and HPV-11 was associated with no significant increase in the risk of aggressiveness. CONCLUSIONS: The age at diagnosis was the main determinant of RRP aggressiveness.
Subject(s)
Papillomaviridae/classification , Papillomavirus Infections/virology , Respiratory Tract Infections/virology , Adolescent , Adult , Child , Child, Preschool , Colombia , Female , Humans , Male , Middle Aged , Retrospective Studies , Young AdultABSTRACT
Objective. Describe factors associated with aggressive forms of recurrent respiratory papillomatosis (RRP). Materials and methods. One hundred eighty-nine RRP cases diagnosed between 1985 and 2009 were identified in pathological records. HPV was detected by the SPF-10 method with broad spectrum primers, (version 1). Results. 113 patients had only one surgery (less aggressive) and 76, two or more interventions (more aggressive). The likelihood of aggressive lesions decreased with increasing age at diagnosis and HPV-11 was associated with no significant increase in the risk of aggressiveness. Conclusions. The age at diagnosis was the main determinant of RRP aggressiveness.
Objetivo. Describir factores asociados con formas agresivas de papilomatosis respiratoria recurrente (PRR). Material y métodos. Se identificaron 189 casos de PRR diagnosticados entre 1985-2009 en registros patológicos. VPH fue detectado por el método SPF-10 con cebadores de amplio espectro, (versión 1). Resultados. 113 casos presentaron una intervención quirúrgica (menos agresivas) y 76, dos o más intervenciones (más agresivas). La probabilidad de lesiones agresivas disminuyó con el aumento de la edad al momento del diagnóstico y el VPH-11 se asoció con aumento no significativo del riesgo de agresividad. Conclusiones. La edad al momento del diagnóstico fue el principal determinante de la agresividad de PRR.
Subject(s)
Adolescent , Adult , Child , Child, Preschool , Female , Humans , Male , Middle Aged , Young Adult , Papillomaviridae/classification , Papillomavirus Infections/virology , Respiratory Tract Infections/virology , Colombia , Retrospective StudiesABSTRACT
BACKGROUND: Knowledge on human papillomavirus (HPV) genotype distribution in recurrent respiratory papillomatosis (RRP) is essential to assess the impact of HPV vaccine. It is provided information for Colombia. METHODS: In all, 189 RRP primary cases diagnosed between 1985 and 2009 were identified from 5 pathology laboratories of Cali and Medellin, Colombia. HPV DNA testing in 129 cases that fulfilled inclusion criteria (available paraffin blocks, amplifiable DNA, and confirmed histologic diagnosis of RRP) was performed by the SPF-10/LiPA25 assay (version 1). RESULTS: Of all cases 36.1% were juvenile (<12 years old) and a majority of adults were males (p = .09); 95% of cases were HPV positive. HPV 6, 11, and 16 contributed to 69%, 27.1%, and 7.8% of all HPV positive cases. Twelve cases (9.3%) showed multiple infections; 8 of these were HPV 6 or 11 positive. CONCLUSIONS: HPV prophylactic vaccine including HPV 6 and 11 may have a major impact against RRP.
Subject(s)
Genetic Predisposition to Disease/epidemiology , Human papillomavirus 11/isolation & purification , Human papillomavirus 6/isolation & purification , Papillomavirus Infections/epidemiology , Papillomavirus Infections/genetics , Respiratory Tract Infections/epidemiology , Respiratory Tract Infections/genetics , Adolescent , Adult , Age Distribution , Child , Child, Preschool , Cohort Studies , Colombia/epidemiology , DNA, Viral/analysis , Female , Genotype , Human papillomavirus 11/genetics , Human papillomavirus 6/genetics , Humans , Male , Middle Aged , Papillomavirus Infections/diagnosis , Papillomavirus Infections/physiopathology , Papillomavirus Vaccines/administration & dosage , Papillomavirus Vaccines/genetics , Polymerase Chain Reaction/methods , Prevalence , Respiratory Tract Infections/diagnosis , Respiratory Tract Infections/physiopathology , Retrospective Studies , Risk Assessment , Severity of Illness Index , Sex Distribution , Urban PopulationABSTRACT
Se estudiaron 56 casos de nefropatía IgA, que se obtuvieron en 506 biopsias renales exitosas efectuadas entre 1980 y 1989 en el Hospital Universitario del Valle, Cali, Colombia. El objetivo fue establecer la prevalencia e incidencia de los hallazgos histoinmunopatológicos y para ello se revisaron 80,005 informes de biopsias elaboradas en ese período. El (59 por ciento) correspondió al sexo femenino. La hematuria aislada fue la presentación de clínica más comúnmente observada (67.8 por ciento) y fue seguida por el síndrome nefrótico (26.8 por ciento). Los depósitos mesangiales percibidos en mayor número fueron los de IgA en 16 casos (28.6 por ciento): 10 (17.8) de IgA más C3 y de IgA más IgG, respectivamente. Todos tenían proliferación mesangial celular y en 25 pacientes (44.6 por ciento) la proliferación mesangial fue mixta, celular y de matriz asociadas. En 7 (12.5 por ciento) se vieron esclerosis focal segmentaria y crecientes, con cambios intersticiales y atrofia tubular en 9 de ellos (16 por ciento), respectivamente. El (5.4 por ciento) 3,156 de los pacientes evolucionaron hacia la insuficiencia renal terminal y fueron transplantados. La nefropatía IgA no es una entidad tan benigna como se sugirió y es la primera causa de la glomerulonefritis primaria y de la hematuria glomerular. Se requieren pruebas urinarias y biopsias renales tempranas para su diagnóstico y manejo precoz (INV.)
Subject(s)
Humans , Biopsy , Glomerulonephritis, IGA , Nephrology , Microscopy, FluorescenceABSTRACT
El higado graso agudo del embarazo es una entidad poco frecuente, de dificil diagnostico y manejo. El pronostico materno-fetal esta relacionado con el diagnostico precoz; cuando no se diagnostica oportunamente, evoluciona hacia una falla hepatica severa. En la actualidad hay muy pocos casos en la literatura medica colombiana, entre ellos 3 descritos previamente en el Hospital Universitario del Valle (HUV), Cali, Colombia en 1970. El presente trabajo adiciona 3 personas mas con esta entidad que se estudiaron en el HUV durante el periodo comprendido entre enero de 1985 y diciembre de 1988. Las caracteristicas clinico-patologicas de las pacientes son muy semejantes a las encontradas por otros autores. El diagnostico temprano con la terminacion rapida del embarazo es la medida terapeutica aceptada en los informes mas recientes de esta entidad
