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Rev Esp Anestesiol Reanim ; 44(2): 70-8, 1997 Feb.
Article in Spanish | MEDLINE | ID: mdl-9148359

ABSTRACT

Low molecular weight heparins are a group of drugs that have only recently been introduced in clinical practice. The are widely used for prophylaxis in thromboembolic disease and are being employed increasingly to treat established venous thrombosis. One way in which these drugs are often used is for prophylaxis in the perioperative period for patients at high risk of developing venous thromboembolism, and the anesthesiologist must therefore be familiar with the main aspects of this application. We review pharmacological characteristics of these drugs as well as the literature on low molecular weight heparins, stressing points of main interest to the anesthesiologist and intensive care recovery unit specialist, namely adverse effects (mainly bleeding) and the implications that use of low molecular weight heparin will have on choice of anesthetic (in particular the dilemma of whether to use local/regional anesthesia).


Subject(s)
Anticoagulants/therapeutic use , Fibrinolytic Agents/therapeutic use , Heparin, Low-Molecular-Weight/therapeutic use , Postoperative Complications/prevention & control , Thromboembolism/prevention & control , Anesthesia, Spinal/adverse effects , Anticoagulants/chemistry , Anticoagulants/pharmacology , Factor Xa Inhibitors , Female , Fibrinolytic Agents/chemistry , Fibrinolytic Agents/pharmacology , Hemorrhage/chemically induced , Hemorrhage/prevention & control , Heparin, Low-Molecular-Weight/antagonists & inhibitors , Heparin, Low-Molecular-Weight/chemistry , Heparin, Low-Molecular-Weight/pharmacology , Humans , Male , Postoperative Complications/chemically induced , Pregnancy , Pregnancy Complications, Hematologic/drug therapy , Protamines/pharmacology , Protamines/therapeutic use , Subarachnoid Hemorrhage/etiology , Subarachnoid Hemorrhage/prevention & control , Thrombin/antagonists & inhibitors
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