ABSTRACT
Peroral endoscopic myotomy (POEM) is an innovative, minimally invasive, endoscopic treatment for esophageal achalasia and other esophageal motility disorders, emerged from the natural orifice transluminal endoscopic surgery procedures, and since the first human case performed by Inoue in 2008, showed exciting results in international level, with more than 4000 cases globally up to now. POEM showed superior characteristics than the standard 100-year-old surgical or laparoscopic Heller myotomy (LHM), not only for all types of esophageal achalasia [classical (I), vigorous (II), spastic (III), Chicago Classification], but also for advanced sigmoid type achalasia (S1 and S2), failed LHM, or other esophageal motility disorders (diffuse esophageal spasm, nutcracker esophagus or Jackhammer esophagus). POEM starts with a mucosal incision, followed by submucosal tunnel creation crossing the esophagogastric junction (EGJ) and myotomy. Finally the mucosal entry is closed with endoscopic clip placement. POEM permitted relatively free choice of myotomy length and localization. Although it is technically demanding procedure, POEM can be performed safely and achieves very good control of dysphagia and chest pain. Gastroesophageal reflux is the most common troublesome side effect, and is well controllable with proton pump inhibitors. Furthermore, POEM opened the era of submucosal tunnel endoscopy, with many other applications. Based on the same principles with POEM, in combination with new technological developments, such as endoscopic suturing, peroral endoscopic tumor resection (POET), is safely and effectively applied for challenging submucosal esophageal, EGJ and gastric cardia tumors (submucosal tumors), emerged from muscularis propria. POET showed up to know promising results, however, it is restricted to specialized centers. The present article reviews the recent data of POEM and POET and discussed controversial issues that need further study and future perspectives.
ABSTRACT
BACKGROUND: Endoscopic submucosal dissection (ESD) is currently considered the minimal invasive endoscopic treatment for early gastric cancer. Most superficial gastric neoplastic lesions are depressed type "0-IIc" (70-80%), while totally flat, classified as type "0-IIb" early gastric cancer, is rarely reported (0.4%). The aim of the present study was to assess the efficacy of narrow band imaging (NBI) magnification endoscopy in identifying type "0-IIb" early gastric cancer and ESD treatment with curative intention. METHODS: Twelve of 615 (2%) patients (10 males, median 72 years), treated by ESD at our center, were diagnosed as type "0-IIb" gastric cancer. Ten had exclusively type "0-IIb", while two had combined types "0-IIb+IIc" and "0-IIa+IIb" gastric cancer. Initial diagnosis was made during screening gastroscopy, while NBI magnification endoscopy combined with indigo-carmine chromoendoscopy were also used. RESULTS: White light endoscopy showed only superficial redness. One patient with signet-ring carcinoma showed whitish appearance. Indigo-carmine chromoendoscopy showed better visualization, while NBI magnification endoscopy revealed abnormal mucosal microsurface and microvascular findings which enabled border marking. ESD with curative intention was completed without complications. Histological examination showed complete (R0) resection, in 10 patients (83%). One patient with positive margins received additional surgery (8%). Mean procedure time was 149 (range 60-190) min. One to six years post-ESD all patients remain alive. CONCLUSIONS: ESD is considered a safe and effective curative treatment for type "0-IIb" gastric cancer, resulting in long-term disease-free survival. NBI magnification endoscopy is effective for accurate optical identification and border marking of type "0-IIb" early gastric cancer.
ABSTRACT
PURPOSE: Overlapping ablations can be used to increase radiofrequency ablation volume. Our goal was to determine, in a porcine model, the relationship of ablation size and temperature for single ablation, and to compare the extent of necrosis resulting from temperature-dependent electrode positioning versus fixed-distance dual ablation. MATERIALS AND METHODS: The experiments were performed in two parts (single and dual ablations). During single ablation in ex vivo porcine livers, maximum necrotic diameter was compared with the diameters at the level at which temperatures reached 60°C, 55°C, and 50°C. Dual ablations were performed using 60°C (group 60C), 55°C (group 55C), and 50°C (group 50C), and distances of 3 cm (group 3cm) and 4.1cm (group 4.1cm) as the starting point (RFA2-start) for the second ablation. RESULTS: The maximum necrotic diameter (3.3 ± 0.6 cm) and the necrotic diameters reached at 60°C (2.8 ± 0.8 cm) and 55°C (2.2 ± 0.7 cm) were significantly greater than that at 50°C (0.9 ± 0.5cm; P < .05). In dual ablations, there was no difference between RFA2-start and the maximum diameter of the preceding and subsequent ablations in all temperature-dependent dual ablations (groups 60C, 55C, and 50C) and in group 3cm. (P > .05) However, there was a significant difference between RFA2-start and maximum diameter of the preceding and subsequent ablations in Group 4.1cm (P = .038), resulting in dumbbell-shaped necrosis. CONCLUSIONS: The necrotic diameter proportionally decreases with the temperature in single ablation. Withdrawing the electrode up to 50° or by 3 cm before reablating results in fusion of the two ablation zones versus withdrawal of 4.1 cm, which results in incomplete necrosis in between two ablation zones.
