1.
2.
J Cutan Pathol
; 48(6): 789-794, 2021 Jun.
Article
in English
| MEDLINE
| ID: mdl-33576042
ABSTRACT
Targeted anticancer therapy is being used with greater frequency and dermatologic toxicities are among the most frequent adverse events of these drugs. However, histopathological features of these adverse events are not yet well characterized. We present two cases of clinically different cutaneous toxicities on two patients with hematologic neoplasia. They were treated with different drugs and in both cases medications shared inhibition of PI3K as mechanism of action. The skin biopsy specimen showed endothelial cell atypia with large nuclei and mitotic figures. To the best of our knowledge, no other cases with these striking histopathologic findings have been reported with PI3K inhibitors or other anticancer targeted therapy.
Subject(s)
Drug Eruptions/pathology , Exanthema/chemically induced , Hematologic Neoplasms/drug therapy , Molecular Targeted Therapy/adverse effects , Phosphoinositide-3 Kinase Inhibitors/adverse effects , Adrenal Cortex Hormones/administration & dosage , Adrenal Cortex Hormones/therapeutic use , Aged , Antineoplastic Agents/toxicity , Benzothiazoles/adverse effects , Benzothiazoles/therapeutic use , Biopsy , Drug Eruptions/drug therapy , Enzyme Inhibitors/administration & dosage , Enzyme Inhibitors/therapeutic use , Female , Hematologic Neoplasms/complications , Humans , Hydroxychloroquine/administration & dosage , Hydroxychloroquine/therapeutic use , Middle Aged , Phenylurea Compounds/adverse effects , Phenylurea Compounds/therapeutic use , Phosphoinositide-3 Kinase Inhibitors/therapeutic use , Pyrazoles/adverse effects , Pyrazoles/therapeutic use , Pyrimidines/adverse effects , Pyrimidines/therapeutic use , Pyrrolidines/adverse effects , Pyrrolidines/therapeutic use , Skin/pathology , Treatment Outcome
3.
Enferm Infecc Microbiol Clin
; 32(4): 266-7, 2014 Apr.
Article
in Spanish
| MEDLINE
| ID: mdl-24287005