[Acute renal failure secondary to hepatic veno-occlusive disease in a bone marrow transplant patient]. / Insuficiencia renal aguda secundaria a enfermedad veno-oclusiva hepática en un paciente con trasplante de médula ósea.

Acute renal failure following bone marrow transplantation is a frequent complication with an incidence ranging 15-30% and with high rates of morbidity and mortality. Numerous potential etiologies can be implicated as chemotherapy regimen, use of nephrotoxic antibiotics, sepsis-induced damage, cyclosporine toxicity and other especific pathologies as graft-v-host disease or veno-occlusive disease of the liver. We report the case of a 41-year-old man who underwent autologous peripheral blood stem cell transplantation and developed and acute renal failure secondary to a fatal veno-occlusive disease of the liver. Incidence, potential predisposing factors, outcome and possibilities of treatment are reviewed.

Insuficiencia renal aguda secundaria a enfermedad veno-oclusiva hepática en un paciente con trasplante de médula ósea / Acute renal failure secondary to hepatic veno-occlusive disease in a bone marrow transplant patient

La incidencia de insuficiencia renal aguda es frecuente en el trasplante de médula ósea con frecuencias que alcanzan 25-30% en algunos trabajos. Entre las causas de insuficiencia renal aguda está la enfermedad veno-oclusiva hepática, entidad con alta mortalidad y con tratamientos en discusión. Presentamos un caso de enfermedad veno-oclusiva hepática con insuficiencia renal aguda y con evolución desfavorable. Se revisa esta patología centrándose en los criterios diagnósticos, las formas de presentación, las medidas preventivas y tratamientos ensayados

Acute renal failure following bone marrow transplantation is a frequent complication with an incidence ranging 15-30% and with high rates of morbidity and mortality. Numerous potential etiologies can be implicated as chemotherapy regimen, use of nephrotoxic antibiotics, sepsis-induced dammage, cyclosporine toxicity and other especific pathologies as graft-v-host disease or veno-occlusive disease of the liver. We report the case of a 41-year-old man who underwent autologous peripheral blood stem cell transplantation and developed and acute renal failure secondary to a fatal veno-occlusive disease of the liver. Incidence, potential predisposing factors, outcome and posibilities of treatment are reviewed