ABSTRACT
BACKGROUND: Chronic airflow obstruction is a key characteristic of chronic obstructive pulmonary disease. We investigated whether isolated small airways obstruction is associated with chronic airflow obstruction later in life. METHODS: We used longitudinal data from 3957 participants of the multinational Burden of Obstructive Lung Disease study. We defined isolated small airways obstruction using the prebronchodilator mean forced expiratory flow rate between 25% and 75% of the forced vital capacity (FVC) (FEF25-75) if a result was less than the lower limit of normal (Subject(s)
Airway Obstruction
, Pulmonary Disease, Chronic Obstructive
, Humans
, Longitudinal Studies
, Pulmonary Disease, Chronic Obstructive/complications
, Pulmonary Disease, Chronic Obstructive/diagnosis
, Airway Obstruction/diagnosis
, Airway Obstruction/etiology
, Vital Capacity
, Forced Expiratory Volume
