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Bioorg Med Chem Lett
; 18(9): 2799-804, 2008 May 01.
Article
in English
| MEDLINE
| ID: mdl-18434143
ABSTRACT
3-Aryl-5-phenyl-(1,2,4)-triazoles were identified as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1). They are active in both in vitro and an in vivo mouse pharmacodynamic (PD) model. The synthesis and structure activity relationships are presented.