ABSTRACT
Two new swartziarboreol diterpenes (1 and 2) and swartziarboreol C were isolated from the petroleum ether extract of the roots of Swartzia langsdorffii. Their structures were elucidated by spectroscopic evidence. The biological activity of the root extracts and 2 was evaluated through bioautography and brine shrimp lethality assays.
Subject(s)
Artemia/drug effects , Diterpenes/isolation & purification , Fabaceae/chemistry , Plants, Medicinal/chemistry , Animals , Brazil , Diterpenes/chemistry , Diterpenes/pharmacology , Molecular Structure , Nuclear Magnetic Resonance, Biomolecular , Plant Roots/chemistryABSTRACT
The methanol extracts of the roots of Lonchocarpus cultratus, L. latifolius and L. subglaucescens, species native to Brazil, were all active in the brine shrimp lethality test. Fractions rich in polyhydroxylated alkaloids were obtained from these extracts and, following acetylation, were analysed by GC-MS leading to the identification of acetylated derivatives of 2,5-trans-dihydroxymethyl-3,4-trans-dihydroxypyrrolidine (1), 1-deoxymannojirimycin, 1-deoxynojirimycin, fagomine and homonojirimycin. Only from L. subglaucescens could a compound with the constitution and relative configuration expected for the penta-acetate of 1 be isolated, and its molecular structure was determined for the first time through extensive spectral data analysis.
