ABSTRACT
INTRODUCTION: We describe temporal trends in the mortality rates and factors associated with AIDS and non-AIDS related mortality at the Evandro Chagas Clinical Research Institute (IPEC), Oswaldo Cruz Foundation (FIOCRUZ). METHODS: Adult patients enrolling from 1986 through 2009 with a minimum follow up of 60 days were included. Vital status was exhaustively checked using patients' medical charts, through active contact with individuals and family members and by linkage with the Rio de Janeiro Mortality database using a previously validated algorithm. The CoDe protocol was used to establish the cause of death. Extended Cox proportional hazards models were used for multivariate modeling. RESULTS: A total of 3530 individuals met the inclusion criteria, out of which 868 (24.6%) deceased; median follow up per patient was 3.9 years (interquartile range 1.7-9.2 years). The dramatic decrease in the overall mortality rates was driven by AIDS-related causes that decreased from 9.19 deaths/100PYs n 1986-1991 to 1.35/100PYs in 2007-2009. Non-AIDS related mortality rates remained stable overtime, at around 1 death/100PYs. Immunodeficiency significantly increased the hazard of both AIDS-related and non-AIDS-related causes of death, while HAART use was strongly associated with a lower hazard of death from either cause. CONCLUSIONS: Our results confirm the remarkable decrease in AIDS-related mortality as the HIV epidemic evolved and alerts to the conditions not traditionally related to HIV/AIDS which are now becoming more frequent, needing careful monitoring.
Subject(s)
Acquired Immunodeficiency Syndrome/drug therapy , Acquired Immunodeficiency Syndrome/mortality , Antiretroviral Therapy, Highly Active , Acquired Immunodeficiency Syndrome/epidemiology , Adolescent , Adult , Brazil/epidemiology , Female , Humans , Incidence , Male , Middle Aged , Temporal Arteries , Young AdultABSTRACT
Em 82 exames parasitológicos de fezes realizados pelo método de sedimentaçäo espontânea, em indivíduos moradores em ruas da Cidade do Rio de Janeiro, foram encontrados ovos de Ascaris lumbricoides em 40 (48,8 por cento), de Trichuris trichiura em 27 (32,9 por cento) e ancilostomídeos 7 (8,5 por cento)
Subject(s)
Adolescent , Adult , Animals , Child , Child, Preschool , Female , Humans , Infant , Male , Middle Aged , Ill-Housed Persons , Helminthiasis/epidemiology , Intestinal Diseases, Parasitic/epidemiology , Ancylostoma/isolation & purification , Ascaris lumbricoides/isolation & purification , Brazil/epidemiology , Feces/parasitology , Helminthiasis/parasitology , Intestinal Diseases, Parasitic/parasitology , Prevalence , Trichuris/isolation & purificationABSTRACT
Stool examination by sedimentation method in 82 homeless individuals living in the streets of Rio de Janeiro City, revealed Ascaris lumbricoides eggs in 40 (48.85%), Trichuris trichiura in 27 (32.9%) and hookworm in 7 (8.5%).
