Content analysis of the nursing diagnosis of ineffective peripheral tissue perfusion in patients with diabetic foot.

AIM: To analyse the content of the nursing diagnosis ineffective peripheral tissue perfusion in patients with diabetic foot. DESIGN: A methodological study with a quantitative approach was performed. METHODS: The analysis was performed between January and May 2021 by 34 nurses with clinical/theoretical/research experience with diabetes or nursing diagnoses. These nurses evaluated the relevance, clarity and precision of 12 diagnosis-specific etiological factors, 22 clinical indicators and their conceptual and operational definitions. FINDINGS: All 12 etiological factors analysed were considered relevant to diagnostic identification. However, five showed inconsistencies regarding the clarity or precision of the operational definitions, requiring adjustments. Regarding the 22 clinical indicators evaluated, all of them presented a Content Validity Index (CVI) that was statistically significant. However, in the indicators, the colour does not return to lowered limb after 1 min of leg elevation, and cold foot had Content Validity Index (CVI) <0.9 regarding relevance and accuracy of operational definitions. CONCLUSIONS: Twelve etiological factors and 22 clinical indicators were validated. Thus, this study revealed new and relevant aspects characterising peripheral perfusion in patients with diabetic foot that have not yet been clinically validated. IMPLICATIONS FOR NURSING PRACTICE: This study contributes to support the professional practice of nurses through the early identification of etiological factors and clinical indicators in persons with diabetic foot. As a proposal, we suggest the inclusion of new defining characteristics and related factors for the nursing diagnosis ineffective peripheral tissue perfusion in the NANDA-I taxonomy. IMPACT: The research highlights new and relevant aspects such as etiological factors and clinical indicators to characterise peripheral perfusion in patients with diabetic foot. Based on these findings, clinical validation is recommended to confirm the relevance of the proposed elements in the population studied for greater reliability and improved diagnostic assessment for the professional practice of nurses. REPORTING METHOD: EQUATOR guidelines were adhered to using the GRRAS checklist for reporting reliability and agreement studies. PATIENT OR PUBLIC CONTRIBUTION: No patient or public contribution.

Urinary incontinence in women: assessment with the aid of standardized nursing terminologies NANDA-I and NOC.

OBJECTIVES: to assess urinary impairment in incontinent women with the aid of standardized nursing terminologies NANDA-I and NOC. METHODS: a cross-sectional study, carried out with 97 women attending the gynecology outpatient clinic of a university hospital. Data collection took place using a form that contained information about NANDA-I diagnoses related to urinary incontinence and NOC Urinary Continence indicators. Statistical analysis was performed to assess the impairment of NOC indicators in the presence of NANDA-I nursing diagnoses. RESULTS: diagnosis Mixed Urinary Incontinence was the most prevalent (43.3%), and, in its presence, the most compromised indicators were voids in appropriate receptacle, gets to toilet between urge and passage of urine and empties bladder completely. CONCLUSIONS: urinary impairment was worse in women with elements of stress and urge urinary incontinence.

Factors associated with deaths from COVID-19 in a region of northeastern Brazil.

INTRODUCTION: There is a need to improve knowledge and understanding of the factors associated with mortality from COVID-19 so that managers and decision-makers can implement strategies to mitigate and control the severe forms of the disease. This study aimed to determine the factors associated with deaths from COVID-19 in the state of Maranhão, in northeastern Brazil. METHODOLOGY: This is a cross-sectional and analytical study with patients with a confirmed diagnosis of COVID-19 who died from March 2020 to January 2022. Simple and multiple logistic regression models were used to assess the association between clinical-epidemiological characteristics and death. The odds ratios were expressed using a 95% confidence interval and a 5% significance level. RESULTS: A total of 386,567 cases of COVID-19 were registered in the period, of which 10,986 died. Risk factors associated with deaths from COVID-19 were male sex, age over 30 years, positive reverse transcriptase-polymerase chain reaction (RT-PCR) result, positive CT scan, and having one or more associated comorbidities. The three comorbidities linked to the highest propensity to die were diabetes mellitus, neurological disease, and obesity. CONCLUSIONS: The study findings support the implementation of strategic actions by health care and surveillance professionals and managers towards reducing the incidence of the risk factors for mortality by COVID-19 in Maranhão.

Platypnea-Orthodeoxia Syndrome: Two Case Reports.

Described for the first time in the middle of the last century, platypnea-orthodeoxia syndrome (POS) is an uncommon condition of positional dyspnea and hypoxemia, triggered by standing and relieved with recumbency. It is most commonly associated with right-to-left shunting through a patent foramen ovale (PFO) or atrial septal defect, however its pathophysiology is not entirely understood. As a rare syndrome, it remains underdiagnosed in many patients. We report two different cases that illustrate the challenge of this diagnosis and therapeutic approach. In the first case, a transesophageal echocardiogram (TEE) showed interatrial communication, ostium secundum type, with bidirectional shunting. Patient underwent a successful percutaneous closure of communication, with no residual shunting and clinical improvement and no positional hypoxemia. In the second case, infectious complications were the cause of hemodynamic changes producing meaningful right-to-left pressure gradients, resulting in POS. After antibiotic treatment there was a major clinical improvement and a second TEE showed bidirectional shunting with no positional variation. It was assumed resolution of POS after treatment of infectious complications with no need for immediate surgery. These two cases, with very distinctive functional and anatomic components, illustrate the challenge of understanding the exact mechanism by which POS results in clinical symptoms. A suggestive history and positional variation of oxygen saturation are very useful clues for its diagnosis in cases of unexplained hypoxemia.

Complex physical therapy employing self-adjusting garment (ReadyWrap®) in breast cancer-related lymphedema cases in Brazilian women: a protocol for a randomized controlled trial.

BACKGROUND: Lymphedema is a common complication following breast cancer treatment. The aim of this study is to evaluate the effectiveness of a self-adjusting compression garment (ReadyWrap®) in reducing (phase 1) and maintaining (phase 2) upper limb volume in women presenting breast cancer-related lymphedema. METHODS: This study will comprise a randomized, controlled, single-blind clinical trial concerning women with breast cancer-related lymphedema undergoing treatment at a public cancer treatment reference hospital in the city of Rio de Janeiro, Brazil. The intervention will be carried out by adapting self-dressing versus the standard treatment of compressive bandaging (phase 1) and compressive mesh (phase 2). Both groups will be assessed at the beginning and end of intensive treatment and followed up for up to 12 months to evaluate immediate and late outcomes. Assessments will be carried out by physical upper limb examination (inspection, palpation, volume, dynamometry, and thermography) and questionnaires application to assess patient's quality of life pertaining to the health, functionality, and symptoms of the affected upper limb, as well adverse effects and adherence to treatment. Data will be analyzed descriptively and analytically through univariate and multiple linear regressions. P values < 0.05 will be considered statistically significant. DISCUSSION: This study will evaluate the effectiveness of a self-adjustable garment (ReadyWrap®) in the treatment of lymphedema secondary to breast cancer in Brazilian women compared to the gold standard treatment for limb volume reduction (phase 1) and maintenance (phase 2) phases comprising, respectively, a compressive bandaging and a compressive mesh. The outcome results will provide data based on both quantitative responses and self-reported participant outcomes. The study will also assess the cost-effectiveness of the ReadyWrap® treatment versus standard care. Finally, we expect to reaffirm one more product/therapy as a treatment for this extremely complex and impactful condition following the data analysis. TRIAL REGISTRATION: NCT04934098 [Clinical trials phase 1]. Registered on June 22, 2021. NCT04881604 [Clinical trials phase 2]. Registered on May 11, 2021.

Pulmonary Embolism of COVID-19: A Year of Reflection.

Introduction The coronavirus disease 2019 (COVID-19) pandemic has brought about significant changes in the medical field. While primarily characterized as a respiratory syndrome, COVID-19 is also associated with vascular events, particularly thrombotic complications. These events can manifest as initial presentations or develop as complications during the course of the disease, predominantly driven by immune-mediated mechanisms. Methods Patients with thrombotic complications followed in the post-COVID-19 thrombosis consult of 2021 were retrospectively analyzed and assessed for predisposing factors for pulmonary embolism (PE), including thrombophilias. Patients underwent reassessments over a minimum six-month period following diagnosis to evaluate vascular reperfusion and the potential discontinuation of anticoagulant therapy. Results All patients with PE exhibited segmental or subsegmental PE. Pulmonary CT angiography revealed that only one patient did not show complete reperfusion after six months of anticoagulant therapy alone. There were no instances of recurrent thrombotic events observed during this observation period. Among the studied patients, hypertension, diabetes, and obesity were identified as the most prevalent predisposing factors. No patients were diagnosed with thrombophilias or other relevant factors. Despite extensive research on the predisposing mechanisms of this complication in recent years, limited data exist regarding patients with this specific complication. Discussion and conclusion Continued research into COVID-19 patients and their complications is crucial for understanding the pathophysiological mechanisms and risk factors associated with these complications. The findings of this study support the existence of a multifactorial mechanism, with a significant pro-inflammatory component exacerbated by pre-existing risk factors, rather than a purely prothrombotic mechanism.

Idiopathic Hypereosinophilic Syndrome: A Case Report.

Idiopathic hypereosinophilic syndrome is a rare condition characterized by persistent severe eosinophilia and organ damage without any apparent cause. A 20-year-old male patient with no significant medical history was admitted to the Emergency Department with retrosternal chest pain, fatigue and asthenia. EKG showed ST elevation I, II, III, aVF, V4-V6 and blood tests showed elevated troponin levels. An echocardiogram was performed revealing severe global left ventricular systolic dysfunction. Further evaluations included cardiac magnetic resonance imaging and endomyocardial biopsy, confirming the diagnosis of eosinophilic myocarditis. The patient was started on systemic corticosteroid therapy, resulting in clinical improvement. The patient was discharged after 12 days of hospitalization, following a recovery of biventricular function and he was told to continue oral corticosteroid therapy at home. Further investigation ruled out other causes of hypereosinophilic syndromes, therefore the diagnosis of idiopathic hypereosinophilic syndrome was assumed. Despite the attempt to reduce corticosteroid therapy, the eosinophil count became elevated again, so the dosage was increased and associated with azathioprine with subsequent favorable analytical evolution. This case highlights the challenges in diagnosing and managing idiopathic hypereosinophilic syndrome and emphasizes the importance of prompt treatment initiation to prevent complications.

Factors associated with multibacillary leprosy in a region of northeastern Brazil.

INTRODUCTION: The analysis of factors associated with multibacillary leprosy is important for the development of strategies to mitigate the disease, which persists as a public health problem in Brazil and the world. The objective of this study was to verify the associations between sociodemographic and clinical-epidemiological variables and multibacillary leprosy in the state of northeastern Brazil. METHODOLOGY: This is a cross-sectional, analytical, and retrospective study, with a quantitative approach, carried out in 16 municipalities in the southwest of Maranhão State, northeastern Brazil. All cases of leprosy reported between January 2008 and December 2017 were considered. Sociodemographic and clinical-epidemiological variables were analyzed using descriptive statistics. The identification of the risk factors associated with multibacillary leprosy was conducted using Poisson regression models. The prevalence ratios and respective 95% confidence intervals were estimated using regression coefficients at a 5% significance level. RESULTS: A total of 3,903 leprosy cases were analyzed. Individuals older than 15 years, males, with less than 8 years of education, with level I, II, or "not evaluated" disability, and with type 1 or 2 or both reactional states were more likely to have multibacillary leprosy. Therefore, these characteristics may be considered risk factors. No protective factors were identified. CONCLUSIONS: The investigation revealed important associations between risk factors and multibacillary leprosy. The findings can be considered during the creation of strategies to control and combat the disease.

The Serious Impact of Comorbidities on Methemoglobinemia: A Case Report.

Methemoglobinemia is a rare, life-threatening condition that occurs when the body is exposed to oxidative stress. We present the case of a 72-year-old female with a past medical history of hypertension, obesity, dyslipidemia, and heart failure who was admitted to the emergency department with altered mental status and respiratory failure. After admission, we also identified an atrioventricular block 2:1, anemia, and skin discoloration. We performed endotracheal intubation and started mechanical ventilation due to respiratory failure; however, the patient retained an oxygen "saturation gap" despite adequate ventilation. In the initial laboratory evaluation, methemoglobinemia was found to be 13%, reaching a maximum level of 16%. An electroencephalogram revealed status epilepticus after her admission to the intensive care unit. Despite all efforts and supportive care, methylene blue therapy was never attempted, and the patient died. Our case emphasizes the importance of a high index of suspicion for methemoglobinemia, especially in the presence of an oxygen "saturation gap," and that despite relatively low levels of methemoglobinemia, it can have a more severe clinical presentation in patients with comorbidities. In these patients, a reduced threshold for administering methylene blue should be taken into account.

Measuring the General and Specific Domains of Self-Esteem: The Short-form of the State Self-Esteem Scale.

Self-esteem is a crucial human nature feature for understanding the social dimensions of individuals' self-concept. One of its characteristics is peoples' malleability to adapt to social contexts, that is, the state self-esteem (SSE). Individuals express SES in three different factors: performance; social success; and physical appearance. Along with three studies, we present evidence of validity of the Short-Form of State Self-Esteem Scale (SSES-S) that measures contextual fluctuations in individuals' self-esteem. In Study 1 (N = 300), we found that the structure of the SSES-S was organized into three correlated factors that exhibited convergent-discriminant validity with measures of trait self-esteem and human values. In Study 2 (N = 281), confirmatory factor analysis indicated that a bifactor measurement model better fit the description of the factorial structure of the SSES-S, which also showed incremental validity concerning trait self-esteem for predicting one criterion. In Study 3 (N = 160), we experimentally manipulated contextual information about self-achievement and showed that the SSES-S is sensitive enough to detect transient fluctuations in self-esteem, especially in the achievement factor. We discussed the limitations and scope of the SSES-S, as its specific focus on measuring undergraduate students' state self-esteem and its implications distinguishing the general and particular domains of this construct.

Urinary incontinence in women: assessment with the aid of standardized nursing terminologies NANDA-I and NOC / Incontinencia urinaria en mujeres: evaluación con la ayuda de terminologías de enfermería estandarizadas NANDA-I y NOC / Incontinência urinária em mulheres: avaliação com auxílio das terminologias padronizadas em enfermagem NANDA-I e NOC

ABSTRACT Objectives: to assess urinary impairment in incontinent women with the aid of standardized nursing terminologies NANDA-I and NOC. Methods: a cross-sectional study, carried out with 97 women attending the gynecology outpatient clinic of a university hospital. Data collection took place using a form that contained information about NANDA-I diagnoses related to urinary incontinence and NOC Urinary Continence indicators. Statistical analysis was performed to assess the impairment of NOC indicators in the presence of NANDA-I nursing diagnoses. Results: diagnosis Mixed Urinary Incontinence was the most prevalent (43.3%), and, in its presence, the most compromised indicators were voids in appropriate receptacle, gets to toilet between urge and passage of urine and empties bladder completely. Conclusions: urinary impairment was worse in women with elements of stress and urge urinary incontinence.

RESUMEN Objetivos: evaluar la afectación urinaria en mujeres incontinentes con la ayuda de las terminologías estandarizadas de enfermería NANDA-I y NOC. Métodos: estudio transversal, realizado con 97 mujeres que asisten a la consulta externa de ginecología de un hospital universitario. La recolección de datos se realizó a través de un formulario que contenía información sobre los diagnósticos de la NANDA-I relacionados con la incontinencia urinaria y los indicadores del resultado NOC Continencia Urinaria. Se realizó análisis estadístico para evaluar el deterioro de los indicadores NOC en presencia de diagnósticos de enfermería NANDA-I. Resultados: el diagnóstico Incontinencia Urinaria Mixta fue el más prevalente (43,3%), y, en su presencia, los indicadores más comprometidos fueron orina en recipiente adecuado, llegar al baño entre el deseo y el paso de la orina y vaciar completamente la vejiga. Conclusiones: la afectación urinaria fue peor en mujeres con elementos de estrés e incontinencia urinaria de urgencia.

RESUMO Objetivos: avaliar o comprometimento urinário em mulheres incontinentes com o auxílio das terminologias padronizadas em enfermagem NANDA-I e NOC. Métodos: estudo transversal, realizado com 97 mulheres em atendimento no ambulatório de ginecologia de um hospital universitário. A coleta de dados ocorreu por meio de formulário que continha informações sobre diagnósticos da NANDA-I relacionados à incontinência urinária e indicadores do resultado NOC Continência Urinária. Foi realizada análise estatística para avaliar o comprometimento dos indicadores da NOC na presença dos diagnósticos de enfermagem da NANDA-I. Resultados: o diagnóstico Incontinência Urinária Mista foi o mais prevalente (43,3%), e, na sua presença, os indicadores mais comprometidos foram urina em recipiente apropriado, chega ao banheiro entre o desejo e a passagem de urina e esvazia a bexiga completamente. Conclusões: o comprometimento urinário demonstrou-se pior nas mulheres com elementos de incontinência urinária de esforço e urgência.

Capacidade de enfrentamento do paciente diagnosticado com hiv/aids / Coping capacity of the patient diagnosed with hiv/aids / Capacidad de afrontamiento del paciente diagnosticado de vih/sida

Introdução: O enfrentamento é designado como uma estratégia desenvolvida pelas pessoas para se adaptarem às circunstâncias. Concernente ao enfrentamento de pessoas vivendo com HIV/AIDS, nota-se uma tentativa maior para alcançar qualidade de vida devido às adversidades sociais, religiosas, mentais e físicas. Logo, a compreensão das condições de enfrentamento e quais fatores podem influenciá-los pode ajudar enfermeiros e outros profissionais da saúde a realizar intervenções para controlar os estressores relacionados à doença. Objetivo: Verificar a presença do diagnóstico de enfermagem "Enfrentamento Ineficaz" em pacientes diagnosticados com HIV/AIDS. Método: Estudo transversal e descritivo, ocorrido em um Centro de Testagem e Aconselhamento (CTA) do sul do Maranhão. Participaram 136 pacientes que responderam a um questionário fechado e auto aplicável que investigou aspectos relacionados ao enfrentamento de pacientes com HIV. Todos os dados foram tabulados e realizada a estatística descritiva. Resultados: Houve predominacia do sexo masculino (72,8%) com idade de até 38 anos (60,9%). Destes, 50,7% se consideram heterossexuais e possuíam mais de oito anos de estudo (70,5%). Entre os participantes, 59,5% declararam possuir bom enfrentamento à doença. Ao aplicar os elementos do diagnóstico de Enfrentamento Ineficaz, foi possível perceber que apenas 1,4% dos entrevistados têm o diagnóstico presente e que provavelmente ele também está presente em 14,7% dos participantes. Conclusão: Esta pesquisa torna-se útil para identificar se há deficiências no processo de enfrentamento da doença, especialmente para os profissionais Enfermeiros que podem verificar o enfrentamento a partir do uso do diagnóstico de Enfermagem.

Introduction: Coping is designated as a strategy developed by people to adapt to circumstances. Concerning the coping of people living with HIV/AIDS, one notices a greater attempt to achieve quality of life due to social, religious, mental and physical adversities. Therefore, understanding the conditions of coping and which factors may influence them can help nurses and other health professionals to make interventions to control the stressors related to the disease. Objective: To verify the presence of the nursing diagnosis "Ineffective Coping" in patients diagnosed with HIV/AIDS. Method: Cross-sectional and descriptive study, carried out at a Counseling and Testing Center (CTA) in southern Maranhão. Participants were 136 patients who answered a closed and self-applicable questionnaire that investigated aspects related to coping in patients with HIV. All data were tabulated and descriptive statistics were performed. Results: There was a predominance of males (72.8%) aged up to 38 years (60.9%). Of these, 50.7% considered themselves heterosexual and had more than eight years of schooling (70.5%). Among the participants, 59.5% declared to have a good coping with the disease. When applying the elements of the diagnosis of Ineffective Coping, it was possible to notice that only 1.4% of the interviewees have the diagnosis present, and that it is probably also present in 14.7% of the participants. Conclusion: This research becomes useful to identify whether there are deficiencies in the disease coping process, especially for Nursing professionals who can verify the coping from the use of the Nursing diagnosis.

Introducción: El afrontamiento es designado como una estrategia desarrollada por las personas para adaptarse a las circunstancias. En relación al coping de las personas que viven con VIH/Sida, se nota un mayor intento de alcanzar calidad de vida debido a las adversidades sociales, religiosas, mentales y físicas. Por lo tanto, comprender las condiciones de afrontamiento y qué factores pueden influir en ellas puede ayudar a las enfermeras y a otros profesionales de la salud a realizar intervenciones para controlar los factores estresantes relacionados con la enfermedad. Objetivo: Verificar la presencia del diagnóstico de enfermería "Afrontamiento Ineficaz" en pacientes diagnosticados de VIH/SIDA. Método: Estudio transversal y descriptivo, realizado en un Centro de Orientación y Test (CTA) del sur de Maranhão. Participaron 136 pacientes que respondieron a un cuestionario cerrado y autoaplicable que investigó aspectos relacionados al afrontamiento en pacientes con VIH. Todos los datos fueron tabulados y se realizó estadística descriptiva. Resultados: Hubo predominio de hombres (72,8%) con edad hasta 38 años (60,9%). De ellos, 50,7% se consideraban heterosexuales y tenían más de ocho años de escolaridad (70,5%). Entre los participantes, 59,5% declararon sobrellevar bien la enfermedad. Al aplicar los elementos del diagnóstico de Afrontamiento Ineficaz, fue posible notar que apenas 1,4% de los entrevistados tienen el diagnóstico presente, y que probablemente también esté presente en 14,7% de los participantes. Conclusiones: Esta investigación se torna útil para identificar si existen deficiencias en el proceso de afrontamiento de la enfermedad, especialmente para los profesionales de Enfermería que pueden verificar el afrontamiento a partir del uso del diagnóstico de Enfermería.

Assessment of main complications of regional anesthesia recorded in an acute pain unit in a tertiary care university hospital: a retrospective cohort

Abstract Background Regional anesthesia has been increasingly used. Despite its low number of complications, they are associated with relevant morbidity. This study aims to evaluate the incidence of complications after neuraxial block and peripheral nerve block. Methods A retrospective cohort study was conducted, and data related to patients submitted to neuraxial block and peripheral nerve block at a tertiary university hospital from January 1, 2011 to December 31, 2017 were analyzed. Results From 10,838 patients referred to Acute Pain Unit, 1093(10.1%) had side effects or complications: 1039 (11.4%) submitted to neuraxial block and 54 (5.2%) to peripheral nerve block. The most common side effects after neuraxial block were sensory (48.5%) or motor deficits (11.8%), nausea or vomiting (17.5%) and pruritus (8.0%); The most common complications: 3 (0.03%) subcutaneous cell tissue hematoma, 3 (0.03%) epidural abscesses and 1 (0.01%) arachnoiditis. 204 of these patients presented sensory or motor deficits at hospital discharge and needed follow-up. Permanent peripheral nerve injury after neuraxial block had an incidence of 7.7:10,000 (0.08%). The most common side effects after peripheral nerve block were sensory deficits (52%) and 21 patients maintained follow-up due to symptoms persistence after hospital discharge. Conclusion Although we found similar incidences of side effects or even lower than those described, major complications after neuraxial block had a higher incidence, particularly epidural abscesses. Despite this, other serious complications, such as spinal hematoma and permanent peripheral nerve injury, are still rare.

Assessment of main complications of regional anesthesia recorded in an acute pain unit in a tertiary care university hospital: a retrospective cohort.

BACKGROUND: Regional anesthesia has been increasingly used. Despite its low number of complications, they are associated with relevant morbidity. This study aims to evaluate the incidence of complications after neuraxial block and peripheral nerve block. METHODS: A retrospective cohort study was conducted, and data related to patients submitted to neuraxial block and peripheral nerve block at a tertiary university hospital from January 1, 2011 to December 31, 2017 were analyzed. RESULTS: From 10,838 patients referred to Acute Pain Unit, 1093(10.1%) had side effects or complications: 1039 (11.4%) submitted to neuraxial block and 54 (5.2%) to peripheral nerve block. The most common side effects after neuraxial block were sensory (48.5%) or motor deficits (11.8%), nausea or vomiting (17.5%) and pruritus (8.0%); The most common complications: 3 (0.03%) subcutaneous cell tissue hematoma, 3 (0.03%) epidural abscesses and 1 (0.01%) arachnoiditis. 204 of these patients presented sensory or motor deficits at hospital discharge and needed follow-up. Permanent peripheral nerve injury after neuraxial block had an incidence of 7.7:10,000 (0.08%). The most common side effects after peripheral nerve block were sensory deficits (52%) and 21 patients maintained follow-up due to symptoms persistence after hospital discharge. CONCLUSION: Although we found similar incidences of side effects or even lower than those described, major complications after neuraxial block had a higher incidence, particularly epidural abscesses. Despite this, other serious complications, such as spinal hematoma and permanent peripheral nerve injury, are still rare.

O Uso da Bandagem Compressiva no Pós-Operatório Imediato Não Está Associado à Dor Aguda Pós-Mastectomia / Use of Compression Bandage in the Immediate Postoperative Period is Not Associated with Post-Mastectomy Acute Pain / El Uso de Vendaje Compresivo en el Postoperatorio Inmediato No se Asocia con Dolor Agudo tras Mastectomía

Introdução: A bandagem cinesiológica é um tratamento não farmacológico de baixo custo, simples e de fácil aplicação, que tem como função atuar na redução da dor, no edema local e na melhora da atividade muscular. Objetivo: Avaliar a associação entre o uso da bandagem compressiva na ocorrência de dor pós-operatória em mulheres submetidas à mastectomia no Hospital do Câncer III do Instituto Nacional de Câncer (HC III/INCA). Método: Ensaio clínico randomizado com 106 mulheres submetidas à mastectomia entre março e novembro de 2021. As pacientes, após sorteio, foram designadas para um grupo controle de cuidados de rotina da instituição e para um grupo intervenção, em que foi acrescida, aos cuidados de rotina, a aplicação da bandagem compressiva na região do plastrão no primeiro dia (D1) do pós-operatório. Foram avaliadas dor, parestesia, amplitude de movimento e síndrome da rede axilar no D1, na primeira semana (D7) e no primeiro mês (D30) após a cirurgia. Resultados: Os dois grupos foram similares com relação aos dados demográficos e clínicos. Não houve diferença significativa na presença de dor no local da aplicação (nas avaliações D7 e D30) sendo 24,1% e 27,8% para o grupo da bandagem compressiva (p=0,102) e 11,8% e 17,6% para o grupo controle (p=0,217). Não houve diferença estatisticamente significativa para qualquer desfecho avaliado. Conclusão: O uso da bandagem compressiva no pós-operatório imediato não esteve associado à dor e a outras complicações nas avaliações de sete e 30 dias de pós-operatório de mastectomias

Introduction: Kinesiological bandage is a low-cost, simple and easy-to-apply non-pharmacological treatment that aims to reduce pain, local edema and improvement of muscle activity. Objective: To evaluate the association between the use of compressive bandage in the occurrence of postoperative pain in women undergoing mastectomy at Cancer Hospital III of the National Cancer Institute (HC III/INCA). Method: One hundred and six women who underwent mastectomy between March and November 2021 participated of this randomized clinical trial. The patients were randomly assigned to a routine care group at the institution and an intervention group, in which the application of a compressive bandage in the breast plastron in the first postoperative day (D1) was added to the routine care. Pain, paresthesia, range of motion and axillary web syndrome were evaluated on the D1, the first week (D7) and the first month (D30) after surgery. Results: The two groups were similar with respect to demographic and clinical data. There was no significant difference in the presence of local pain (at D7 and D30) in 24.1% and 27.8% for the compressive bandage group (p=0.102) and 11.8% and 17.6% for the control group (p=0.217). There were no other statistically significant differences for any outcome assessed. Conclusion: The use of compressive bandage in the immediate postoperative period was not associated with pain and other complications in the 7th and 30th days after mastectomies

Introducción: El vendaje kinesiológico es un tratamiento no farmacológico de bajo costo, sencillo y fácil de aplicar, cuya función es disminuir el dolor, el edema local y mejorar la actividad muscular. Objetivo: Evaluar la asociación entre el uso de vendaje compresivo y la aparición de dolor posoperatorio en mujeres sometidas a mastectomía en el Hospital del Cáncer III del Instituto Nacional del Cáncer (HC III/INCA). Método: Ciento seis mujeres sometidas a mastectomía entre marzo y noviembre de 2021 participaron en este ensayo clínico aleatorizado. Los pacientes fueron asignados aleatoriamente a un grupo de atención de rutina en la institución y a un grupo de intervención, en los que se agregó a la atención de rutina la aplicación de un vendaje compresivo en la región del plastrón en el primer día (D1) del postoperatorio. El dolor, las parestesias, el rango de movimiento y el síndrome de red axilar se evaluaron el D1, la primera semana (D7) y el primer mes (D30) después de la cirugía. Resultados: Los dos grupos fueron similares con respecto a los datos demográficos y clínicos. No hubo diferencia significativa en la presencia de dolor en el sitio de aplicación (en las evaluaciones D7 y D30) con 24,1% y 27,8% para el grupo de vendaje compresivo (p=0,102) y 11,8% y 17,6% para el grupo control (p=0,217). No hubo diferencias estadísticamente significativas para ninguno de los resultados evaluados. Conclusión: El uso de vendaje compresivo en el posoperatorio inmediato, no se asoció con dolor y otras complicaciones en las evaluaciones de 7 y 30 días después de mastectomías

Empirical ozone isopleths at urban and suburban sites through evolutionary procedure-based models.

Ozone (O3) is a reactive oxidant that causes chronic effects on human health, vegetation, ecosystems and materials. This study aims to create O3 isopleths in urban and suburban environments, based on machine learning with air quality data collected from 2001 to 2017 at urban (EA) and suburban (CC) monitoring stations from Madrid (Spain). Artificial neural network (ANN) models have powerful fitting performance, describing correctly several complex and nonlinear relationships such as O3 and his precursors (VOC and NOx). Also, ANN learns from the experience provided by data, contrary to mechanistic models based on the fundamental laws of natural sciences. The determined isopleths showed a different behaviour of the VOC-NOx-O3 system compared to the one achieved with a mechanistic model (EKMA curve): e.g. for constant NOx concentrations, O3 concentrations decreased with VOC concentrations in the ANN model. Considering the difficulty to model all the phenomena (and acquired all the required data) that influences O3 concentrations, the statistical models may be a solution to describe this system correctly. The applied methodology is a valuable tool for defining mitigation strategies (control of precursors' emissions) to reduce O3 concentrations. However, as these models are obtained by air quality data, they are not geographical transferable.

[Prevalence and factors associated with non-enrollment for kidney transplant]. / Prevalência e fatores associados a não inscrição para transplante renal.

This study evaluated the prevalence and factors associated with lack of enrollment for kidney transplant among patients in chronic dialysis in Greater Metropolitan Fortaleza, Ceará, Brazil. The sample excluded patients with insufficient clinical status and those already in pre-kidney transplant evaluation. A semi-structured questionnaire was applied, including options for the question, "What is the main reason why you are not enrolled for kidney transplant?" Prevalence of patients considered fit but not enrolled or in pre- kidney transplant evaluation was 50.7%. The main reasons were fear of failure/loss of grafting (32.5%), difficulty with transportation or access to tests (20.9%), and temporary personal or family problems (13.7%). In the multivariate analysis, the variables associated with fear of failure or loss of graft were female sex (OR = 1.763; 95%CI: 1.224-2.540) and end-stage renal disease (ESRD) due to hypertension (OR = 1.732; 95%CI: 1.178-2.547), while monthly income (number of minimum wages) showed a protective association (OR = 0.882; 95%CI: 0.785-0.991). Time on dialysis (months) was a risk factor for difficulty with transportation and access to tests (OR = 1.004; 95%CI: 1.001-1.007), and female sex showed a protective association (OR = 0.576; 95%CI: 0.368-0.901). These results show high prevalence of patients in dialysis not enrolled on the kidney transplant waitlist. The main causes were lack of information and lack of access. Female sex, low income, and ESRD due to hypertension were risk factors for lack of enrollment on the kidney transplant waitlist due to fear of loss of graft, resulting from lack of information on this treatment modality. Male sex and longer time on dialysis were risk factors for difficulty in access to kidney transplant.

Este estudo avaliou a prevalência e os fatores associados a não procura por transplante renal entre pacientes em diálise crônica na Região Metropolitana de Fortaleza, Ceará, Brasil. Foram excluídos os pacientes sem condições clínicas e aqueles em avaliação pré-transplante renal. Um questionário semiestruturado foi aplicado, incluindo opções para a pergunta "Qual o principal motivo pelo qual o senhor/senhora não está inscrito(a) para o transplante renal?". A prevalência de pacientes considerados aptos, mas não inscritos e nem em avaliação pré-transplante renal foi de 50,7%. As principais causas foram: receio de insucesso/perda do enxerto (32,5%), dificuldade de transporte e acesso aos exames (20,9%) e problemas pessoais ou familiares temporários (13,7%). Em análise múltipla, as variáveis associadas a risco de receio do insucesso/perda do enxerto foram: sexo feminino (OR = 1,763; IC95%: 1,224-2,540) e doença renal dialítica (DRC 5-D) por hipertensão (OR = 1,732; IC95%: 1,178-2,547), tendo a renda mensal (salários mínimos) uma associação de proteção (OR = 0,882; IC95%: 0,785-0,991). O tempo em diálise (meses) foi um fator de risco para a dificuldade de transporte e acesso aos exames (OR = 1,004; IC95%: 1,001-1,007) e o sexo feminino apresentou uma associação de proteção (OR = 0,576; IC95%: 0,368-0,901). Esses resultados mostram elevada prevalência de pacientes em diálise fora de lista para transplante renal. As principais causas são reflexo da desinformação e falta de acesso. Sexo feminino, baixa renda e DRC 5-D por hipertensão foram os fatores de risco para a não procura por transplante renal por receio de perda do enxerto, reflexo da carência de informações sobre a modalidade. Sexo masculino e maior tempo em diálise foram os fatores de risco para a dificuldade de acesso à terapia.

Este estudio evalúo la prevalencia y los factores asociados a la no búsqueda de un trasplante renal entre pacientes con diálisis crónica en la Región Metropolitana de Fortaleza, Ceará, Brasil. Se excluyeron a pacientes sin condiciones clínicas y aquellos en evaluación pre-trasplante renal . Se aplicó un cuestionario semiestructurado, incluyendo opciones a la pregunta "¿cuál es el principal motivo por el cual usted no está inscrito(a) para un trasplante renal?" La prevalencia de pacientes considerados aptos, pero no inscritos y ni en evaluación pre-trasplante renal fue de un 50,7%. Las principales causas fueron: recelo al fracaso/pérdida del injerto (32,5%), dificultad de transporte y acceso a los exámenes (20,9%), así como problemas personales o familiares temporales (13,7%). En el análisis múltiple, las variables asociadas al riesgo del recelo al fracaso/pérdida del injerto fueron de sexo femenino (OR = 1,763; IC95%: 1,224-2,540) y enfermedad renal dialítica (DRC 5-D) por hipertensión (OR = 1,732; IC95%: 1,178-2,547), teniendo la renta mensual (salarios mínimos) una asociación de protección (OR = 0,882; IC95%: 0,785-0,991). El tiempo en diálisis (meses) fue un factor de riesgo para la dificultad en el transporte y acceso a los exámenes (OR = 1,004; IC95%: 1,001-1,007), y el sexo femenino tuvo una asociación de protección (OR = 0,576; IC95%: 0,368-0,901). Estos resultados muestran la elevada prevalencia de pacientes en diálisis fuera de la lista para transplante renal. Las principales causas son reflejo de la desinformación y falta de acceso. Sexo femenino, baja renta y DRC 5-D por hipertensión fueron factores de riesgo para la no búsqueda de trasplante renal por recelo a la pérdida del injerto, reflejo de la carencia de información sobre la modalidad. Sexo masculino y mayor tiempo en diálisis fueron factores de riesgo para la dificultad de acceso a la terapia. izará la atención a las vulnerabilidades individuales desde la perspectiva de la salud integral.

Long-term impact of early initiation of enzyme replacement therapy in 34 MPS VI patients: A resurvey study.

Patients with mucopolysaccharidosis type VI (MPS VI) present with a wide range of disease severity and clinical manifestations, with significant functional impairment and shortened lifespan. Enzyme replacement therapy (ERT) with galsulfase has been shown to improve clinical and biochemical parameters including patient survival, quality of life and growth. The present study is a resurvey of 34 Brazilian MPS VI patients with rapidly progressive disease (classical phenotype) who initiated ERT with galsulfase under five years of age and had been on ERT until data collection in 2019, with few exceptions (n = 4 patients who died before 2019). Anthropometric measures, urinary glycosaminoglycans, and data regarding cardiac, orthopedic, neurologic, sleep apnea, hearing and ophthalmologic outcomes were filled in by specialists. Pubertal development, clinical complications, hospitalizations, and surgeries were also assessed. In this resurvey study, treatment with galsulfase has shown to be safe and well tolerated in MPS VI patients who initiated ERT under the age of 5 years and who have been undergoing ERT for approximately 10 years. Mortality rate suggests that early initiation of ERT may have a positive impact on patients' survival, improving but not preventing disease progression and death. MPS VI patients on ERT also showed improved growth velocity and the pubertal development was normal in all surviving patients. Follow-up data on pneumonia and hospitalization suggest that early ERT may have a protective effect against major respiratory complications. Cardiac valve disease progressed since their prior evaluation and spinal cord compression was observed in a large number of patients, suggesting that these disease complications were not modified by ERT.

Prevalência e fatores associados a não inscrição para transplante renal / Prevalence and factors associated with non-enrollment for kidney transplant / Prevalencia y factores asociados a la no inscripción para un trasplante renal

Resumo: Este estudo avaliou a prevalência e os fatores associados a não procura por transplante renal entre pacientes em diálise crônica na Região Metropolitana de Fortaleza, Ceará, Brasil. Foram excluídos os pacientes sem condições clínicas e aqueles em avaliação pré-transplante renal. Um questionário semiestruturado foi aplicado, incluindo opções para a pergunta "Qual o principal motivo pelo qual o senhor/senhora não está inscrito(a) para o transplante renal?". A prevalência de pacientes considerados aptos, mas não inscritos e nem em avaliação pré-transplante renal foi de 50,7%. As principais causas foram: receio de insucesso/perda do enxerto (32,5%), dificuldade de transporte e acesso aos exames (20,9%) e problemas pessoais ou familiares temporários (13,7%). Em análise múltipla, as variáveis associadas a risco de receio do insucesso/perda do enxerto foram: sexo feminino (OR = 1,763; IC95%: 1,224-2,540) e doença renal dialítica (DRC 5-D) por hipertensão (OR = 1,732; IC95%: 1,178-2,547), tendo a renda mensal (salários mínimos) uma associação de proteção (OR = 0,882; IC95%: 0,785-0,991). O tempo em diálise (meses) foi um fator de risco para a dificuldade de transporte e acesso aos exames (OR = 1,004; IC95%: 1,001-1,007) e o sexo feminino apresentou uma associação de proteção (OR = 0,576; IC95%: 0,368-0,901). Esses resultados mostram elevada prevalência de pacientes em diálise fora de lista para transplante renal. As principais causas são reflexo da desinformação e falta de acesso. Sexo feminino, baixa renda e DRC 5-D por hipertensão foram os fatores de risco para a não procura por transplante renal por receio de perda do enxerto, reflexo da carência de informações sobre a modalidade. Sexo masculino e maior tempo em diálise foram os fatores de risco para a dificuldade de acesso à terapia.

Abstract: This study evaluated the prevalence and factors associated with lack of enrollment for kidney transplant among patients in chronic dialysis in Greater Metropolitan Fortaleza, Ceará, Brazil. The sample excluded patients with insufficient clinical status and those already in pre-kidney transplant evaluation. A semi-structured questionnaire was applied, including options for the question, "What is the main reason why you are not enrolled for kidney transplant?" Prevalence of patients considered fit but not enrolled or in pre- kidney transplant evaluation was 50.7%. The main reasons were fear of failure/loss of grafting (32.5%), difficulty with transportation or access to tests (20.9%), and temporary personal or family problems (13.7%). In the multivariate analysis, the variables associated with fear of failure or loss of graft were female sex (OR = 1.763; 95%CI: 1.224-2.540) and end-stage renal disease (ESRD) due to hypertension (OR = 1.732; 95%CI: 1.178-2.547), while monthly income (number of minimum wages) showed a protective association (OR = 0.882; 95%CI: 0.785-0.991). Time on dialysis (months) was a risk factor for difficulty with transportation and access to tests (OR = 1.004; 95%CI: 1.001-1.007), and female sex showed a protective association (OR = 0.576; 95%CI: 0.368-0.901). These results show high prevalence of patients in dialysis not enrolled on the kidney transplant waitlist. The main causes were lack of information and lack of access. Female sex, low income, and ESRD due to hypertension were risk factors for lack of enrollment on the kidney transplant waitlist due to fear of loss of graft, resulting from lack of information on this treatment modality. Male sex and longer time on dialysis were risk factors for difficulty in access to kidney transplant.

Resumen: Este estudio evalúo la prevalencia y los factores asociados a la no búsqueda de un trasplante renal entre pacientes con diálisis crónica en la Región Metropolitana de Fortaleza, Ceará, Brasil. Se excluyeron a pacientes sin condiciones clínicas y aquellos en evaluación pre-trasplante renal . Se aplicó un cuestionario semiestructurado, incluyendo opciones a la pregunta "¿cuál es el principal motivo por el cual usted no está inscrito(a) para un trasplante renal?" La prevalencia de pacientes considerados aptos, pero no inscritos y ni en evaluación pre-trasplante renal fue de un 50,7%. Las principales causas fueron: recelo al fracaso/pérdida del injerto (32,5%), dificultad de transporte y acceso a los exámenes (20,9%), así como problemas personales o familiares temporales (13,7%). En el análisis múltiple, las variables asociadas al riesgo del recelo al fracaso/pérdida del injerto fueron de sexo femenino (OR = 1,763; IC95%: 1,224-2,540) y enfermedad renal dialítica (DRC 5-D) por hipertensión (OR = 1,732; IC95%: 1,178-2,547), teniendo la renta mensual (salarios mínimos) una asociación de protección (OR = 0,882; IC95%: 0,785-0,991). El tiempo en diálisis (meses) fue un factor de riesgo para la dificultad en el transporte y acceso a los exámenes (OR = 1,004; IC95%: 1,001-1,007), y el sexo femenino tuvo una asociación de protección (OR = 0,576; IC95%: 0,368-0,901). Estos resultados muestran la elevada prevalencia de pacientes en diálisis fuera de la lista para transplante renal. Las principales causas son reflejo de la desinformación y falta de acceso. Sexo femenino, baja renta y DRC 5-D por hipertensión fueron factores de riesgo para la no búsqueda de trasplante renal por recelo a la pérdida del injerto, reflejo de la carencia de información sobre la modalidad. Sexo masculino y mayor tiempo en diálisis fueron factores de riesgo para la dificultad de acceso a la terapia. izará la atención a las vulnerabilidades individuales desde la perspectiva de la salud integral.

Assessment of tissular integrity in patients with diabetic foot.

OBJECTIVE: Evaluate the impairment of tissue integrity in patients with diabetic foot and verify its association with time of diagnosis of the disease. METHODS: Cross-sectional study conducted with 134 patients in an outpatient clinic located in the Northeast region of Brazil. A semi-structured questionnaire was used for data collection, which was subjected to descriptive analysis and the Mann-Whitney U non-parametric test. RESULTS: Indicators with the lowest average score were: skin temperature, sweating, skin lesions, right and left pedal pulses, right and left tibial pulses. Patients less than ten years old had worse scores on thickness, elasticity, right tibial pulse and tissue integrity. Those with a diagnosis time of more than ten years had a greater impairment of sensation and right pulse. CONCLUSION: All indicators showed some impairment of tissue integrity, and the time of diagnosis of the disease was associated with six of these.