Caffeine Increases Endurance Performance via Changes in Neural and Muscular Determinants of Performance Fatigability.

PURPOSE: In the present study, we tested the hypothesis that caffeine would increase endurance performance via attenuation of neural and muscular determinants of performance fatigability during high-intensity, whole-body exercise. METHODS: Ten healthy males cycled until exhaustion (89% ± 2% of V̇O2max) after the ingestion of caffeine or placebo. During another four visits, the same exercise was performed after either caffeine or placebo ingestion but with exercise discontinued after completing either 50% or 75% of the duration of placebo trial. An additional trial with caffeine ingestion was also performed with interruption at the placebo time to exhaustion (isotime). Performance fatigability was measured via changes in maximal voluntary contraction, whereas neural and muscular determinants of performance fatigability were quantified via preexercise to postexercise decrease in quadriceps voluntary activation (VA) and potentiated twitch force, respectively. RESULTS: Compared with the placebo, caffeine increased time to exhaustion (+14.4 ± 1.6%, P = 0.017, 314.4 ± 47.9 vs 354.9 ± 40.8 s). Caffeine did not change the rate of decline in maximal voluntary contraction (P = 0.209), but caffeine reduced the twitch force decline at isotime when stimulating at single twitch (-58.6 ± 22.4 vs -45.7 ± 21.9%, P = 0.014) and paired 10 Hz electrical stimuli (-37.3 ± 13.2 vs -28.2 ± 12.9%, P = 0.025), and reduced the amplitude of electromyography signal during cycling at isotime (P = 0.034). The decline in VA throughout the trial was lower (P = 0.004) with caffeine (-0.5 ± 4.2%) than with placebo (-5.8 ± 8.5%). Caffeine also maintained peripheral oxygen saturation at higher levels (95.0 ± 1.9%) than placebo (92.0 ± 6.2%, P = 0.016). CONCLUSIONS: Caffeine ingestion improves performance during high-intensity, whole-body exercise via attenuation of exercise-induced reduction in VA and contractile function.

Caffeine alters the breathing pattern during high-intensity whole-body exercise in healthy men.

PURPOSE: The current study investigated the effect of caffeine on the breathing pattern during a high-intensity whole-body exercise. METHODS: Using a randomized, crossover, counterbalanced, and double-blind design, twelve healthy men ingested either 5 mg.kg-1 of caffeine or cellulose (placebo) one hour before performing a high-intensity whole-body exercise (i.e., work rate corresponding to 80% of the difference between the gas exchange threshold and maximal oxygen uptake) until the limit of tolerance. Ventilatory and metabolic responses were recorded throughout the trial and at task failure. RESULTS: Caffeine ingestion increased time to task failure in relation to the placebo (368.1 ± 49.6 s vs. 328.5 ± 56.6 s, p = 0.005). Caffeine also increased tidal volume and inspiratory time throughout the exercise (p < 0.05). Compared to task failure with placebo, task failure with caffeine intake was marked by higher (p < 0.05) minute ventilation (134.8 ± 16.4 vs. 147.6 ± 18.2 L.min-1), the ventilatory equivalent of oxygen consumption (37.8 ± 4.2 vs. 41.7 ± 5.5 units), and respiratory exchange ratio (1.12 ± 0.10 vs. 1.19 ± 0.11 units). CONCLUSION: In conclusion, ingestion of caffeine alters the breathing pattern by increasing tidal volume and lengthening the inspiratory phase of the respiratory cycle. These findings suggest that caffeine affects the ventilatory system, which may account, in part, for its ergogenic effects during high-intensity whole-body exercises.