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Microsc Microanal ; 22(3): 640-8, 2016 06.
Article in English | MEDLINE | ID: mdl-27212049

ABSTRACT

The aim of the present work was to investigate birefringence and morphology of the secretory-stage enamel organic extracellular matrix (EOECM), and structural and mechanical properties of mature enamel of upper incisors from adult rats that had been treated with pamidronate disodium (0.5 mg/kg/week for 56 days), using transmitted polarizing and bright-field light microscopies (TPLM and BFLM), energy-dispersive X-ray (EDX) analysis, scanning electron microscopy (SEM) and microhardness testing. BFLM showed no morphological changes of the EOECM in pamidronate and control groups, but TPLM revealed a statistically significant reduction in optical retardation values of birefringence brightness of pamidronate-treated rats when compared with control animals (p0.05). The present study indicates that pamidronate can affect birefringence of the secretory-stage EOECM, which does not seem to be associated with significant changes in morphological and/or mechanical properties of mature enamel.


Subject(s)
Dental Enamel/drug effects , Dental Enamel/ultrastructure , Diphosphonates/pharmacology , Animals , Bone Density Conservation Agents/pharmacology , Dental Enamel/chemistry , Dental Enamel/cytology , Microscopy, Electron, Scanning , Pamidronate , Rats , X-Rays
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