ABSTRACT
The use of monoclonal antibodies (mAbs) has become broader because of their recognized effectiveness in the treatment of autoimmune, neoplastic, and inflammatory diseases. Consequently, hypersensitivity reactions (HSR) secondary to mAbs are being reported more often, and each mAb-related HSR presents specific features. This article discusses the main biological agents and associated HSR, the clinical presentation of such reactions, and the role of tryptase and skin testing in the diagnosis. Rapid drug desensitization procedures to mAbs enable selected allergic patients to receive full therapeutic doses in a safe manner and are also discussed.
Subject(s)
Allergens/immunology , Antibodies, Monoclonal/therapeutic use , Desensitization, Immunologic/methods , Drug Hypersensitivity/epidemiology , Immunotherapy/methods , Antibodies, Monoclonal/immunology , Drug Hypersensitivity/therapy , Humans , Immunoglobulin E/metabolism , Immunotherapy/adverse effects , Prevalence , Skin Tests , Tryptases/immunologyABSTRACT
A poroqueratose de Mibelli é uma dermatose rara, autossômica dominante, evidenciada como um distúrbio queratósico com risco de transformação maligna. O paciente geralmente procura o médico em virtude das alterações cutâneas caracterizadas como um aspecto estético desfavorável.
