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1.
Braz. j. med. biol. res ; 55: e12109, 2022. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1403906

ABSTRACT

PREDICT is a tool designed to estimate the benefits of adjuvant therapy and the overall survival of women with early breast cancer. The model uses clinical, histological, and immunohistochemical variables. This study aimed to evaluate the model's performance in a Brazilian population. We assessed the discrimination and calibration of the PREDICT model to estimate overall survival (OS) in five and ten years of follow-up in a cohort of 873 women with early breast cancer diagnosed from January 2001 to December 2016. A total of 743 patients had estrogen receptor (ER)-positive and 130 had ER-negative tumors. The area under the receiver operating characteristic (ROC) curve (AUC) for discrimination was 0.72 (95%CI: 0.66-0.78) at five years and 0.67 (95%CI: 0.61-0.72) at ten years for women with ER-positive tumors. The AUC was 0.72 (95%CI: 0.62-0.81) at five years and 0.67 (95%CI: 0.54-0.77) at ten years for women with ER-negative tumors. The predicted survival in ER-positive tumors was 91.0% (95%CI: 90.2-91.6%) at five years and 79.3% (95%CI: 77.7-81.0%) at ten years, and the observed survival 90.7% (95%CI: 88.6-92.9%) and 77.2% (95%CI: 73.4-81.4%), respectively. The predicted survival in ER-negative tumors was 84.5% (95%CI: 82.5-86.6%) at five years and 75.0% (95%CI: 71.6-78.5%) at ten years, and the observed survival 76.3% (95%CI: 69.1-84.3%) and 67.9% (95%CI: 58.6-78.6%), respectively. In conclusion, PREDICT was accurate to estimate OS in women with ER-positive tumors and overestimated the OS in women with ER-negative tumors.

2.
Reprod Domest Anim ; 47(3): 379-84, 2012 Jun.
Article in English | MEDLINE | ID: mdl-21883514

ABSTRACT

We investigated the effect of the leukaemia inhibitory factor (LIF) alone or in association with FSH on the in vitro culture (IVC) of caprine preantral follicles. Preantral follicles >200 µm in size were isolated and cultured for 18 days in basic medium either alone (control) or supplemented with LIF (10 or 50 ng/ml) in the absence or presence of FSH. Every 6 days, follicular survival, growth and antrum formation were evaluated. At the end of the culture period, the oocytes underwent in vitro maturation (IVM), and their viability and chromatin configuration were assessed. Follicles of the control group and those cultured in 10 ng/ml LIF maintained the structural integrity (particularly the preservation of the basement membrane) when compared to the oocytes cultured in 50 ng/ml LIF, regardless the presence of FSH. In the absence of FSH, the percentage of antrum formation after 18 days of culture in the 50 ng/ml LIF group was significantly lower than in either the control group or the 10 ng/ml LIF group. However, this effect was not observed in the presence of FSH. The rate of resumption of meiosis was significantly higher in the 50 ng/ml LIF group in the absence of FSH in comparison with the control and 10 ng/ml LIF groups. Metaphase II was observed only when follicles were cultured in a combination of FSH and 50 ng/ml LIF. In conclusion, LIF alone does not interfere with antral formation and oocyte growth, but at concentration of 50 ng/ml and combined with FSH, it promotes oocyte maturation.


Subject(s)
Follicle Stimulating Hormone/pharmacology , Goats/physiology , Leukemia Inhibitory Factor/pharmacology , Ovarian Follicle/drug effects , Ovarian Follicle/metabolism , Animals , Dose-Response Relationship, Drug , Drug Therapy, Combination , Female , Follicle Stimulating Hormone/administration & dosage , Leukemia Inhibitory Factor/administration & dosage , Tissue Culture Techniques
4.
Phys Rev B Condens Matter ; 54(2): 1302-1307, 1996 Jul 01.
Article in English | MEDLINE | ID: mdl-9985402
5.
Phys Rev Lett ; 76(7): 1126-1129, 1996 Feb 12.
Article in English | MEDLINE | ID: mdl-10061640
6.
Phys Rev B Condens Matter ; 51(21): 15540-15546, 1995 Jun 01.
Article in English | MEDLINE | ID: mdl-9978512
7.
Phys Rev B Condens Matter ; 50(18): 13528-13532, 1994 Nov 01.
Article in English | MEDLINE | ID: mdl-9975547
8.
9.
Phys Rev B Condens Matter ; 49(9): 6404-6407, 1994 Mar 01.
Article in English | MEDLINE | ID: mdl-10011645
10.
Phys Rev B Condens Matter ; 48(6): 3976-3982, 1993 Aug 01.
Article in English | MEDLINE | ID: mdl-10008847
11.
Phys Rev B Condens Matter ; 46(9): 5496-5498, 1992 Sep 01.
Article in English | MEDLINE | ID: mdl-10004335
12.
Phys Rev B Condens Matter ; 45(2): 1023-1026, 1992 Jan 01.
Article in English | MEDLINE | ID: mdl-10001147
14.
15.
Phys Rev B Condens Matter ; 38(1): 946-949, 1988 Jul 01.
Article in English | MEDLINE | ID: mdl-9945301
17.
São Paulo; IDPC; 1988. 93 p. il..
in Portuguese | DANTEPAZZANESE, SESSP-IDPCACERVO | ID: dan-3089
18.
Phys Rev B Condens Matter ; 31(7): 4694-4697, 1985 Apr 01.
Article in English | MEDLINE | ID: mdl-9936418
19.
Phys Rev B Condens Matter ; 31(5): 3093-3099, 1985 Mar 01.
Article in English | MEDLINE | ID: mdl-9936166
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