ABSTRACT
BACKGROUND: Starch nanoparticles have become among the most interesting nanovehicles for drug delivery because of their relatively easy synthesis, biocompatibility, and numerous botanical sources. Starch nanoparticles obtained from green bananas were cross-linked with citric acid and loaded with ß-carotene. RESULTS: Mean particle size, encapsulation efficiency, and ß-carotene release in simulated gastric and intestinal fluids and food simulants were studied. Cross-linked nanoparticles showed higher loading efficiency and encapsulation capacity, indicating that they can accommodate more molecules than their unmodified counterparts, while mathematical models showed a diffusion of released ß-carotene into food simulant media. CONCLUSIONS: Cross-linked nanoparticles showed more controlled release under gastric conditions, mainly in the simulated intestinal fluid, indicating that they are suitable as vehicles for intestine-specific targeting. This controlled released was also observed in food simulants, with lower release values in the more aqueous simulants. © 2019 Society of Chemical Industry.
