ABSTRACT
INTRODUCTION: Enterococcus faecalis is a constant microbiome that plays an inevitable role in the etiology of peri radicular lesions after endodontic treatment, chronic and, apical periodontitis and, recently, in periimplantitis. The effective biomechanical preparation and the use of potent irrigating solutions will permit bacterial neutralization and toxin inactivation, leading to the success of endodontic treatment. This study aimed to evaluate the "anti-microbial" efficacy of simvastatin (SMV) against E. faecalis as an endodontic irrigant. MATERIALS AND METHODS: In this invitro experimental study, the antimicrobial efficacy of SMV was evaluated against E. faecalis using the agar diffusion method. The samples were divided randomly into the following groups. GROUP 1: SMV solution 1 µM/L concentration, GROUP 2: SMV solution 5 µM/L concentration, GROUP 3: SMV solution 10 µM/L concentration, GROUP 4: 2% chlorhexidine gluconate (CHX) solution (positive control), and GROUP 5: normal saline (negative control). Linear measurement was done by measuring the zones of inhibition around the medicaments in the cavities in millimeters. Results were tabulated. RESULTS: The results of the study have shown the zone of inhibition of Group 4 (2% CHX solution) is 19 mm, which demonstrated the best outcome. When comparing the test samples, Group 3 (SMV solution 10 M/L concentration) has the best zone of inhibition, measuring 14 mm, followed by Group 2 (SMV solution 5 M/L concentration), which is 9 mm. CONCLUSION: The results of this in vitro study have proven that SMV's anti-microbial activity, albeit less potent than CHX in this in vitro investigation, has demonstrated that it can be utilized as an efficient endodontic irrigant.
