ABSTRACT
A case of acute renal failure probably associated with topiramate is discussed. The patient showed a significant, progressive increase in creatinine and serum urea values 5 days after topiramate treatment onset, as well as diminished creatinine clearance and non-oliguric acute renal failure requiring haemodialysis initiation. Upon topiramate discontinuance altered parameters became normal. No significant alterations were revealed by ultrasonography and renal biopsy. Coincidence in time and the absence of other factors suggest topiramate as likely cause of renal failure.
Subject(s)
Acute Kidney Injury/chemically induced , Anticonvulsants/adverse effects , Fructose/analogs & derivatives , Fructose/adverse effects , Acute Kidney Injury/physiopathology , Adult , Humans , Kidney Function Tests , Male , Renal Dialysis , TopiramateABSTRACT
The purification grade of d-aminolevulinic acid dehydrase, the specific enzyme activity, the Michaelis constant and the optimum pH are determined in extracts from embryos and endosperms of Pinus pinea seeds germinated at different stages of germination. On the other hand the influence of levulinic acid, sodium cyanide, sodium malonate, sodium arsenite and sodium azide on the activity of d-aminolevulinic acid dehydrase has also been studied.
