[The dynamics of the healing of an infected fracture of mandibular bone exposed to andekalin and kontrikal]. / Dinamika zazhivleniia infitsirovannogo pereloma nizhnecheliustnoi kosti pri vozdeistvii andekalina i kontrikala.

Infected mandibular fracture was simulated in rats. 10 percent calcium chloride solution (control) or andecalin (10 U/Kg) and contrykal (2.5000 U/kg) were administered to fracture site by vacuum electrophoresis. Histologic examination has revealed that andecalin activated the exudative phase of inflammation and decelerated the proliferative processes. A contrary effect was induced by contrykal: rapidly decreasing exudation, activation of osteoclastic resorption of necrotic bone and of osteogenesis processes.

[The protein content and cathepsin D activity of the mandibular bone in rats during fracture healing]. / Soderzhanie belka i aktivnost' katepsina D v kosti nizhnei cheliusti krys pri zazhivlenii pereloma.

Soluble and total protein content and cathepsin D activity were measured in rat mandibular bone tissue during healing of a fracture treated with proteolytic enzymes (andecalin) or protease inhibitors (contrykal) electrophoresis. Contrykal essentially elevated collagen content in mandibular bone tissue and reduced lysosomal enzymes activity. Andecalin had no noticeable effect on the levels of total protein and collagen, but it significantly increased the activity of cathepsin D. The findings evidence that local contrykal electrophoresis in the focus of injury creates an effective concentration of the drug that enhances the fracture healing and prevents the development of pyoinflammatory complications.